The three-dimensional positions of atoms in protein molecules define their structure and
their roles in biological processes. The more precisely atomic coordinates are determined …

A host of new technologies are under development to improve the quality and reproducibility
of cryoelectron microscopy (cryoEM) grid preparation. Here we have systematically …

Myosin-2 is essential for processes as diverse as cell division and muscle contraction.
Dephosphorylation of its regulatory light chain promotes an inactive,'shutdown'state with the …

Porphyromonas gingivalis, an asaccharolytic member of the Bacteroidetes, is a keystone
pathogen in human periodontitis that may also contribute to the development of other …

Cryo-electron microscopy (cryo-EM) is capable of producing reconstructed 3D images of
biomolecules at near-atomic resolution. However, raw cryo-EM images are only highly …

Acinetobacter baumannii is a Gram-negative bacterium primarily associated with hospital-
acquired, often multidrug-resistant (MDR) infections. The ribosome-targeting antibiotics …

Roundworm parasite infections are a major cause of human and livestock disease
worldwide and a threat to global food security. Disease control currently relies on …

Cryo-electron microscopy (cryo-EM) is a powerful tool for investigating the structure of
macromolecules under near-native conditions. Especially in the context of membrane …

KOBRA (KirchOff Biological Rod Algorithm) is an algorithm and software package designed
to perform dynamical simulations of elongated biomolecules such as those containing alpha …