Formulating drugs into nanoparticles offers many attractive advantages over free drugs
including improved bioavailability, minimized toxic side effects, enhanced drug delivery …

Self-assembled nanostructures are highly promising for controlled delivery of therapeutic
and diagnostic agents. However, for conventional drug delivery nanosystems, there exist …

Minimizing drug leakage in systemic circulation, synchronizing the in vivo fate of multiple
drugs, and precisely controlling tumor locoregional drug release, remain challenging for …

Abstract High expression of indoleamine 2, 3-dioxygenase 1 (IDO1) is a major cause of
tumor induced immunosuppression, and appears to be associated with poor prognosis in …

Many drug molecules that are currently in the market suffer from short half-life, poor
absorption, low specificity, rapid degradation, and resistance development. The design and …

Amphiphilic drug conjugates can self-assemble into nanovehicles for cancer drug delivery,
but the key is to design stable yet intracellular labile drug linkers for drug retention during …

The inception and development of supramolecular chemistry have provided a vast library of
supramolecular structures and materials for improved practice of medicine. In the context of …

Despite the progress made with the recent clinical use of the anticancer compound
cabazitaxel, the efficacy in patients remains unsatisfactory, largely due to the high in vivo …

Atherosclerosis (AS) is a lipid-driven chronic inflammatory disease occurring at the arterial
subendothelial space. Macrophages play a critical role in the initiation and development of …

A supramolecular nanoprodrug based on the host–guest complexation of water-soluble
pillar [5] arene (WP5) and a boronate ester linked curcumin (Cur) was constructed, which …