Understanding the mechanisms that trigger chromatin compaction, its patterns, and the
factors they depend on, is a fundamental and still open question in Biology. Chromatin …

While recent experiments revealed that some pioneer transcription factors (TFs) can bind to
their target DNA sequences inside a nucleosome, the binding dynamics of their target …

Access to the eukaryotic genome is key to the regulation of such DNA processes as
transcription, replication and repair. About three-quarters of the human genome is stored …

Transcription factor (TF) proteins bind to DNA to regulate gene expression. Normally,
accessibility to DNA is required for their function. However, in the nucleus, the DNA is often …

Chromatin compaction and gene accessibility are orchestrated by assembly and
disassembly of nucleosomes. Although the disassembly process was widely studied, little is …

Linker histones are epigenetic regulators that bind to nucleosomes and alter chromatin
structures and dynamics. Biophysical studies have revealed two binding modes in the linker …

Protein flexibility and disorder is emerging as a crucial modulator of chromatin structure.
Histone tail disorder enables transient binding of different molecules to the nucleosomes …

We propose a methodology for the study of protein-DNA electrostatic interactions and apply
it to clarify the effect of histone tails in nucleosomes. This method can be used to correlate …

The FACT (facilitates chromatin transcription) complex, comprising SPT16 and SSRP1,
conducts structural alterations during nucleosome unwrapping. Our previous cryoelectron …

Abstract Background H2A. B, the most divergent histone variant of H2A, can significantly
modulate nucleosome and chromatin structures. However, the related structural details and …