[HTML][HTML] Chromatin compaction multiscale modeling: a complex synergy between theory, simulation, and experiment
Understanding the mechanisms that trigger chromatin compaction, its patterns, and the
factors they depend on, is a fundamental and still open question in Biology. Chromatin …
factors they depend on, is a fundamental and still open question in Biology. Chromatin …
Nucleosome allostery in pioneer transcription factor binding
While recent experiments revealed that some pioneer transcription factors (TFs) can bind to
their target DNA sequences inside a nucleosome, the binding dynamics of their target …
their target DNA sequences inside a nucleosome, the binding dynamics of their target …
[HTML][HTML] Nucleosome unwrapping and unstacking
H Kono, H Ishida - Current Opinion in Structural Biology, 2020 - Elsevier
Access to the eukaryotic genome is key to the regulation of such DNA processes as
transcription, replication and repair. About three-quarters of the human genome is stored …
transcription, replication and repair. About three-quarters of the human genome is stored …
[HTML][HTML] Nucleosomal DNA dynamics mediate Oct4 pioneer factor binding
Transcription factor (TF) proteins bind to DNA to regulate gene expression. Normally,
accessibility to DNA is required for their function. However, in the nucleus, the DNA is often …
accessibility to DNA is required for their function. However, in the nucleus, the DNA is often …
Dynamics of the nucleosomal histone H3 N-terminal tail revealed by high precision single-molecule FRET
K Lehmann, S Felekyan, R Kühnemuth… - Nucleic Acids …, 2020 - academic.oup.com
Chromatin compaction and gene accessibility are orchestrated by assembly and
disassembly of nucleosomes. Although the disassembly process was widely studied, little is …
disassembly of nucleosomes. Although the disassembly process was widely studied, little is …
Elucidating the influence of linker histone variants on chromatosome dynamics and energetics
DC Woods, J Wereszczynski - Nucleic acids research, 2020 - academic.oup.com
Linker histones are epigenetic regulators that bind to nucleosomes and alter chromatin
structures and dynamics. Biophysical studies have revealed two binding modes in the linker …
structures and dynamics. Biophysical studies have revealed two binding modes in the linker …
Emergence of chromatin hierarchical loops from protein disorder and nucleosome asymmetry
A Sridhar, SE Farr, G Portella… - Proceedings of the …, 2020 - National Acad Sciences
Protein flexibility and disorder is emerging as a crucial modulator of chromatin structure.
Histone tail disorder enables transient binding of different molecules to the nucleosomes …
Histone tail disorder enables transient binding of different molecules to the nucleosomes …
[HTML][HTML] The role of histone tails in nucleosome stability: An electrostatic perspective
A Bendandi, AS Patelli, A Diaspro… - Computational and …, 2020 - Elsevier
We propose a methodology for the study of protein-DNA electrostatic interactions and apply
it to clarify the effect of histone tails in nucleosomes. This method can be used to correlate …
it to clarify the effect of histone tails in nucleosomes. This method can be used to correlate …
[HTML][HTML] Partial replacement of nucleosomal DNA with human FACT induces dynamic exposure and acetylation of histone H3 N-terminal tails
Y Tsunaka, H Ohtomo, K Morikawa, Y Nishimura - Iscience, 2020 - cell.com
The FACT (facilitates chromatin transcription) complex, comprising SPT16 and SSRP1,
conducts structural alterations during nucleosome unwrapping. Our previous cryoelectron …
conducts structural alterations during nucleosome unwrapping. Our previous cryoelectron …
[HTML][HTML] Molecular mechanism of histone variant H2A. B on stability and assembly of nucleosome and chromatin structures
J Peng, C Yuan, X Hua, Z Zhang - Epigenetics & chromatin, 2020 - Springer
Abstract Background H2A. B, the most divergent histone variant of H2A, can significantly
modulate nucleosome and chromatin structures. However, the related structural details and …
modulate nucleosome and chromatin structures. However, the related structural details and …