Obesity is one of the major health burdens of the 21st century as it contributes to the growing
prevalence of its related comorbidities, including insulin resistance and type 2 diabetes …

Insulin resistance (IR) is fundamental to the development of type 2 diabetes (T2D) and is
present in most prediabetic (preDM) individuals. Insulin resistance has both heritable and …

Abstract Type 2 diabetes (T2D) is a very prevalent, multisystemic, chronic metabolic disorder
closely related to atherosclerosis and cardiovascular diseases. It is characterised by …

Type 2 diabetes (T2D) is one of the main current threats to human health. Both T2D and its
numerous clinical complications are related to mitochondrial dysfunction and oxidative …

Background and aims Non‐alcoholic fatty liver disease (NAFLD) is becoming increasingly
prevalent and nutrition intervention remains the most important therapeutic approach for …

Studies investigating the potential link between adult pre-menopausal obesity [as measured
by body mass index (BMI)] and triple-negative breast cancer have been inconsistent. Recent …

As a major site of glucose uptake following a meal, skeletal muscle has an important role in
whole-body glucose metabolism. Evidence in humans and animal models of insulin …

Alterations in muscle mitochondrial substrate preference have been postulated to play a
major role in the pathogenesis of muscle insulin resistance. In order to examine this …

The GLUT4 and PI3K/AKT signaling pathways are the key sensors of energy status and they
regulate glucose and lipid metabolism. Phloretin activates the PI3K/AKT pathway by …

Catalpol was tested for various disorders including diabetes mellitus. Numerous molecular
mechanisms have emerged supporting its biological effects but with little information …