[HTML][HTML] Medicinal plants as a drug alternative source for the antigout therapy in Morocco

NE Daoudi, M Bouhrim, H Ouassou, M Bnouham - Scientifica, 2020 - hindawi.com
Background. The gout is a metabolic disease that is associated with a high level of uric acid
in the blood. This disease is treated with some medications that aim to reduce serum urate …

8, 8-bis-(Dihydroconiferyl)-diferulate displayed impressive cytotoxicity towards a panel of human and animal cancer cells

AT Mbaveng, F Damen, MGF Guefack, SB Tankeo… - Phytomedicine, 2020 - Elsevier
Background Recalcitrant cancers appear as a major obstacle to chemotherapy, prompting
scientists to intensify the search for novel drugs to tackle the cell lines expressing multi-drug …

Cytotoxicity of a naturally occuring spirostanol saponin, progenin III, towards a broad range of cancer cell lines by induction of apoptosis, autophagy and necroptosis

AT Mbaveng, GF Chi, GS Nguenang… - Chemico-Biological …, 2020 - Elsevier
This study was aimed to investigate the cytotoxic potential of a natural compound, progenin
III on a broad range of cancer cell lines, including various sensitive and drug-resistant …

Cytotoxic Constituents of the Bark of Hypericum roeperianum towards Multidrug‐Resistant Cancer Cells

MGF Guefack, F Damen, AT Mbaveng… - Evidence‐Based …, 2020 - Wiley Online Library
The global cancer burden remains a serious concern with the alarming incidence of one in
eight men and one in eleven women dying in developing countries. This situation is …

Exploring the ring potential of 2, 4-diaminopyrimidine derivatives towards the identification of novel caspase-1 inhibitors in Alzheimer's disease therapy

RO Kumi, OS Soremekun, AR Issahaku… - Journal of molecular …, 2020 - Springer
Pro-inflammatory activation of caspase-1 in the neurodegenerative pathway has been
associated with age-dependent cognitive impairment and Alzheimer's disease (AD) in …

'Polymorphism-aided'Selective Targeting and Inhibition of Caspase-6 by a Novel Allosteric Inhibitor Towards Efficient Alzheimer's Disease Treatment

RO Kumi, C Agoni, AR Issahaku, FA Olotu… - Cell Biochemistry and …, 2020 - Springer
The predominance of Alzheimer's disease (AD) among the aged remains a global
challenge. As such, the search for alternative and effective therapeutic options continuous …

'Polymorphism-aided'Selective Targeting and Inhibition of Caspase-6 by a Novel Allosteric Inhibitor Towards Efficient Alzheimer's Disease Treatment

KR Oduro, A Clement, IA Rashid… - Cell Biochemistry and …, 2020 - search.proquest.com
The predominance of Alzheimer's disease (AD) among the aged remains a global
challenge. As such, the search for alternative and effective therapeutic options continuous …