Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease
worldwide. NAFLD stages range from simple steatosis (NAFL) to non-alcoholic …

Lysosomes are of major importance for the regulation of cellular cholesterol homeostasis.
Food-derived cholesterol and cholesterol esters contained within lipoproteins are delivered …

Fatty acids (FAs) are essential nutrients, but how they are transported into cells remains
unclear. Here, we show that FAs trigger caveolae-dependent CD36 internalization, which in …

Adipocytes are critical for ovarian cancer cells to home to the omentum, but the metabolic
changes initiated by this interaction are unknown. To this end, we carried out unbiased mass …

Background The presence of foamy macrophages and microglia containing intracellular
myelin remnants is a pathological hallmark of neurodegenerative disorders such as multiple …

Thyroid function is central in the control of physiological and pathophysiological processes.
Studies in animal models and human research have determined that thyroid hormones …

Abstract Purpose of Review Atherosclerosis is a chronic disease characterized by lipid
retention and inflammation in the artery wall. The retention and oxidation of low-density …

For long time bilirubin was only considered as a potentially dangerous sign of liver diseases,
but it now appears clear that it is also a powerful signaling molecule. Together with potent …

Fatty acid synthase, a key enzyme of de novo lipogenesis, is an attractive therapeutic target
in cancer. The novel fatty acid synthase inhibitor, TVB-3664, shows anti-cancer activity in …

The pathogenesis of diabetic kidney disease is a complex process caused by both
glucotoxicity and lipotoxicity due to lipid accumulation. In cases of diabetic animals, lipid …