Tumor mutational burden (TMB), defined as the number of somatic mutations per megabase
of interrogated genomic sequence, varies across malignancies. Panel sequencing–based …

Protein–protein interactions (PPIs) have pivotal roles in life processes. The studies showed
that aberrant PPIs are associated with various diseases, including cancer, infectious …

Several species of intestinal bacteria have been associated with enhanced efficacy of
checkpoint blockade immunotherapy, but the underlying mechanisms by which the …

Neoantigens arise from mutations in cancer cells and are important targets of T cell-
mediated anti-tumor immunity. Here, we report the first open-label, phase Ib clinical trial of a …

Diabetes mellitus is a chronic heterogeneous metabolic disorder with complex
pathogenesis. It is characterized by elevated blood glucose levels or hyperglycemia, which …

Immune checkpoint blockade therapy has become a major weapon in fighting cancer.
Antibody drugs, such as anti-PD-1 and anti-PD-L1, demonstrate obvious advantages such …

Colorectal cancer (CRC) is among the most lethal and prevalent malignancies in the world
and was responsible for nearly 881,000 cancer-related deaths in 2018. Surgery and …

Human-to-Human Coronavirus Transmission in Vietnam The authors describe transmission
of 2019-nCoV from a father, who had flown with his wife from Wuhan to Hanoi, to the son …

Background Lung cancer is made up of distinct subtypes, including non–small-cell lung
cancer (NSCLC) and small-cell lung cancer (SCLC). Although overall mortality from lung …

Background The efficacy and safety of the anti–programmed death ligand 1 (PD-L1)
monoclonal antibody atezolizumab, as compared with those of platinum-based …