Mitochondrial diseases are clinically heterogeneous disorders caused by a wide spectrum
of mutations in genes encoded by either the nuclear or the mitochondrial genome …

Exercise is fundamental for good health, whereas physical inactivity underpins many chronic
diseases of modern society. It is well appreciated that regular exercise improves metabolism …

Motivation Accurate prediction of cancer drug response (CDR) is challenging due to the
uncertainty of drug efficacy and heterogeneity of cancer patients. Strong evidences have …

Doxorubicin is a commonly used chemotherapeutic agent for the treatment of a range of
cancers, but despite its success in improving cancer survival rates, doxorubicin is cardiotoxic …

Cardiovascular mortality is a major cause of death among in type 2 diabetes (T2DM).
Endothelial dysfunction (ED) is a well-known important risk factor for the development of …

The emergence of small open reading frame (sORF)-encoded peptides (SEPs) is rapidly
expanding the known proteome at the lower end of the size distribution. Here, we show that …

Mitochondria supply ATP essential for synaptic transmission. Neurons face exceptional
challenges in maintaining energy homoeostasis at synapses. Regulation of mitochondrial …

Nonalcoholic fatty liver diseases (NAFLDs), especially nonalcoholic steatohepatitis (NASH),
have become a major cause of liver transplant and liver-associated death. However, the …

Mitochondrial disorders comprise a molecular and clinically diverse group of diseases that
are associated with mitochondrial dysfunction leading to multi-organ disease. With recent …

Astroglia or astrocytes, the most abundant cells in the brain, are interposed between
neuronal synapses and microvasculature in the brain gray matter. They play a pivotal role in …