RNA-based therapies, including RNA molecules as drugs and RNA-targeted small
molecules, offer unique opportunities to expand the range of therapeutic targets. Various …

The current global health threat by the novel coronavirus disease 2019 (COVID-19) requires
an urgent deployment of advanced therapeutic options available. The role of …

CRISPR–Cas gene editing and messenger RNA-based protein replacement therapy hold
tremendous potential to effectively treat disease-causing mutations with diverse cellular …

Messenger RNA (mRNA)-based therapeutics hold the potential to cause a major revolution
in the pharmaceutical industry because they can be used for precise and individualized …

Nucleic acids are a promising type of therapeutic for the treatment of a wide range of
conditions, including cancer, but they also pose many delivery challenges. For efficient and …

Bone-marrow endothelial cells in the haematopoietic stem-cell niche form a network of
blood vessels that regulates blood-cell traffic as well as the maintenance and function of …

CRISPR/Cas9-based genome editing has quickly emerged as a powerful breakthrough
technology for use in diverse settings across biomedical research and therapeutic …

RNA molecules (eg, siRNA, microRNA, and mRNA) have shown tremendous potential for
immunomodulation and cancer immunotherapy. They can activate both innate and adaptive …

Recent years have witnessed tremendous developments and breakthroughs in the field of
RNA-based therapeutics. The distinct mechanisms of exogenous RNAs and analogs …

The complex tumor microenvironment is a most important factor in cancer development. The
biological microenvironment is composed of a variety of barriers including the extracellular …