Pathogenesis of preterm birth: bidirectional inflammation in mother and fetus

ES Green, PC Arck - Seminars in immunopathology, 2020 - Springer
Abstract Preterm birth (PTB) complicates 5–18% of pregnancies globally and is a leading
cause of maternal and fetal morbidity and mortality. Most PTB is spontaneous and idiopathic …

[HTML][HTML] The female response to seminal fluid

JE Schjenken, SA Robertson - Physiological reviews, 2020 - journals.physiology.org
Seminal fluid is often assumed to have just one function in mammalian reproduction,
delivering sperm to fertilize oocytes. But seminal fluid also transmits signaling agents that …

The ovarian stroma as a new frontier

HM Kinnear, CE Tomaszewski, FL Chang… - …, 2020 - rep.bioscientifica.com
Historically, research in ovarian biology has focused on folliculogenesis, but recently the
ovarian stroma has become an exciting new frontier for research, holding critical keys to …

A single-cell atlas of adult Drosophila ovary identifies transcriptional programs and somatic cell lineage regulating oogenesis

A Jevitt, D Chatterjee, G Xie, XF Wang, T Otwell… - PLOS …, 2020 - journals.plos.org
Oogenesis is a complex developmental process that involves spatiotemporally regulated
coordination between the germline and supporting, somatic cell populations. This process …

Inflammaging is associated with shifted macrophage ontogeny and polarization in the aging mouse ovary

Z Zhang, F Schlamp, L Huang, H Clark… - …, 2020 - rep.bioscientifica.com
The fertility of women declines sharply after age 35 and is essentially lost upon menopause
at age 51. The ovary plays an important part in aging-associated changes in women's …

Immunophenotypic profiles in polycystic ovary syndrome

C Hu, B Pang, Z Ma, H Yi - Mediators of Inflammation, 2020 - Wiley Online Library
Polycystic ovary syndrome (PCOS) a long‐known endocrinopathy and one of the most
common endocrine‐reproductive‐metabolic disorders in women, which can lead to infertility …

CD206+ M2-like macrophages are essential for successful implantation

Y Ono, O Yoshino, T Hiraoka, E Sato, Y Fukui… - Frontiers in …, 2020 - frontiersin.org
Macrophages (MΦs) play important roles in implantation. Depletion of CD11b+ pan-MΦs in
CD11b-diphtheria-toxin-receptor (DTR) mice is reported to cause implantation failure due to …

Endometrial immunity for embryo implantation and pregnancy establishment

J Kitazawa, F Kimura, A Nakamura… - The Tohoku journal of …, 2020 - jstage.jst.go.jp
The uterus is an organ for raising the fetus, and its lumen is lined by the endometrium. The
endometrium is an important site for the implantation and maturation of fertilized eggs. The …

[HTML][HTML] Roadmap to pregnancy in the first 7 days post-insemination in the cow: Immune crosstalk in the corpus luteum, oviduct, and uterus

AK Talukder, MA Marey, K Shirasuna, K Kusama… - Theriogenology, 2020 - Elsevier
The first 7 days post-insemination are critical for establishment of pregnancy. The pre-
ovulatory luteinizing hormone (LH) surge induces ovulation through disruption of the follicle …

ST2 signaling in the tumor microenvironment

CP Chang, MH Hu, YP Hsiao, YC Wang - … : The Role of Interleukins–Part A, 2020 - Springer
Abstract Suppression of tumorigenicity 2 (ST2), also known as interleukin-1 receptor-like 1
(IL1RL1), is one of the natural receptors of IL-33. Three major isoforms, ST2L …