Acellular pertussis vaccine components: today and tomorrow

KK Dewan, B Linz, SE DeRocco, ET Harvill - Vaccines, 2020 - mdpi.com
Pertussis is a highly communicable acute respiratory infection caused by Bordetella
pertussis. Immunity is not lifelong after natural infection or vaccination. Pertussis outbreaks …

The epidemic of erythromycin-resistant Bordetella pertussis with limited genome variation associated with pertussis resurgence in China

K Yao, J Deng, X Ma, W Dai, Q Chen… - Expert Review of …, 2020 - Taylor & Francis
ABSTRACT Background The resurgence of Bordetella pertussis infections leading to
whooping cough is a concern in many parts of the world. The number of pertussis cases in …

Next-generation pertussis vaccines based on the induction of protective T cells in the respiratory tract

CN Chasaide, KHG Mills - Vaccines, 2020 - mdpi.com
Immunization with current acellular pertussis (aP) vaccines protects against severe
pertussis, but immunity wanes rapidly after vaccination and these vaccines do not prevent …

Impact of maternal dTpa vaccination on the incidence of pertussis in young infants

F Friedrich, MC Valadão, M Brum, T Comaru… - PloS one, 2020 - journals.plos.org
Introduction Pertussis is an important public health problem worldwide, especially in infants.
An increase in the incidence in many countries occurred after 2010, including Brazil. In …

Effect of FHA and Prn on Bordetella pertussis colonization of mice is dependent on vaccine type and anatomical site

A Zeddeman, E van Schuppen, KE Kok, M van Gent… - PLoS …, 2020 - journals.plos.org
Bordetella pertussis vaccine escape mutants that lack expression of the pertussis antigen
pertactin (Prn) have emerged in vaccinated populations in the last 10–20 years. Additionally …

Surfaceome analysis of Australian epidemic Bordetella pertussis reveals potential vaccine antigens

LDW Luu, S Octavia, C Aitken, L Zhong, MJ Raftery… - Vaccine, 2020 - Elsevier
Since acellular vaccines (ACV) were introduced in Australia, epidemic Bordetella pertussis
strains changed from single nucleotide polymorphism (SNP) cluster II to SNP cluster I. Our …

Allele frequencies of Bordetella pertussis virulence-associated genes identified from pediatric patients with severe respiratory infections

T Imamura, K Shoji, N Kono, M Kubota… - Journal of Infection and …, 2020 - Elsevier
Bordetella pertussis (B. pertussis) infection occasionally causes severe respiratory infections
in children. Potential association between virulence-associated gene alleles and severe …

[HTML][HTML] Genome diversity and evolutionary characteristics of clinical isolates of Bordetella pertussis circulating in Iran

S Saedi, A Safarchi, M Noofeli, K Tadayon… - Iranian Journal of …, 2020 - ncbi.nlm.nih.gov
Materials and Methods: The genetic diversity and evolutionary characteristics of circulating
Iranian isolates of Bordetella pertussis during February 2015 to October 2018 was …

A profile of the Simplexa™ Bordetella Direct assay for the detection and differentiation of Bordetella pertussis and Bordetella parapertussis in nasopharyngeal swabs

DC Dominguez - Expert Review of Molecular Diagnostics, 2020 - Taylor & Francis
Introduction Pertussis is a highly contagious respiratory infection caused by Bordetella
pertussis and to minor extent B. parapertussis. Despite high vaccination coverage …

Aberration detection of pertussis from the Mazandaran province, Iran, from 2012 to 2018: Application of discrete wavelet transform

Y Alimohamadi, SM Zahraei, M Karami… - Journal of Acute …, 2020 - journals.lww.com
Objective: To define the level of alarm threshold for pertussis aberrations and to detect the
aberrations of the reported suspected cases of pertussis from the Mazandaran province in …