[HTML][HTML] PET radiopharmaceuticals for Alzheimer's disease and Parkinson's disease diagnosis, the current and future landscape
BC Uzuegbunam, D Librizzi, B Hooshyar Yousefi - Molecules, 2020 - mdpi.com
Ironically, population aging which is considered a public health success has been
accompanied by a myriad of new health challenges, which include neurodegenerative …
accompanied by a myriad of new health challenges, which include neurodegenerative …
Positron emission tomography imaging with [18F] flortaucipir and postmortem assessment of Alzheimer disease neuropathologic changes
AS Fleisher, MJ Pontecorvo, MD Devous, M Lu… - JAMA …, 2020 - jamanetwork.com
Importance Positron emission tomography (PET) may increase the diagnostic accuracy and
confirm the underlying neuropathologic changes of Alzheimer disease (AD). Objective To …
confirm the underlying neuropathologic changes of Alzheimer disease (AD). Objective To …
Molecular tools to detect alloforms of Aβ and Tau: Implications for multiplexing and multimodal diagnosis of Alzheimer's disease
The advancements in the field of imaging and diagnostics have been benefitted by the
concurrent expansion of molecular probes space to monitor the diverse biological targets …
concurrent expansion of molecular probes space to monitor the diverse biological targets …
[HTML][HTML] Aβ plaques
LC Walker - Free neuropathology, 2020 - ncbi.nlm.nih.gov
Aβ plaques are one of the two lesions in the brain that define the neuropathological
diagnosis of Alzheimer's disease. Plaques are highly diverse structures; many of them …
diagnosis of Alzheimer's disease. Plaques are highly diverse structures; many of them …
Detecting earlier stages of amyloid deposition using PET in cognitively normal elderly adults
Objective To examine the feasibility of using cross-sectional PET to identify cognitive
decliners among β-amyloid (Aβ)-negative cognitively normal (CN) elderly adults. Methods …
decliners among β-amyloid (Aβ)-negative cognitively normal (CN) elderly adults. Methods …
[HTML][HTML] Post-mortem analyses of PiB and flutemetamol in diffuse and cored amyloid-β plaques in Alzheimer's disease
MD Ikonomovic, CJ Buckley, EE Abrahamson… - Acta …, 2020 - Springer
Specificity and sensitivity of positron emission tomography (PET) radiopharmaceuticals
targeting fibrillar amyloid-β (Aβ) deposits is high for detection of neuritic Aβ plaques, a …
targeting fibrillar amyloid-β (Aβ) deposits is high for detection of neuritic Aβ plaques, a …
Diffusion MRI biomarkers of white matter microstructure vary nonmonotonically with increasing cerebral amyloid deposition
Beta amyloid (Aβ) accumulation is the earliest pathological marker of Alzheimer's disease
(AD), but early AD pathology also affects white matter (WM) integrity. We performed a cross …
(AD), but early AD pathology also affects white matter (WM) integrity. We performed a cross …
[HTML][HTML] Identification of a nanomolar affinity α-synuclein fibril imaging probe by ultra-high throughput in silico screening
Small molecules that bind with high affinity and specificity to fibrils of the α-synuclein (αS)
protein have the potential to serve as positron emission tomography (PET) imaging probes …
protein have the potential to serve as positron emission tomography (PET) imaging probes …
Fluorine-18: A radionuclide with diverse range of radiochemistry and synthesis strategies for target based PET diagnosis
Fluorine-18 is one of the most widely used radionuclides for the production of
radiopharmaceuticals for positron emission tomography (PET). The radiolabeling methods …
radiopharmaceuticals for positron emission tomography (PET). The radiolabeling methods …
[HTML][HTML] Appropriate reference region selection of 18F-florbetaben and 18F-flutemetamol beta-amyloid PET expressed in Centiloid
The Centiloid (CL) is a method for standardizing amyloid beta (Aβ) quantification through
different ligands and methods. To find the most appropriate reference region to reduce the …
different ligands and methods. To find the most appropriate reference region to reduce the …