Fat-on-a-chip models for research and discovery in obesity and its metabolic comorbidities

M McCarthy, T Brown, A Alarcon… - … Engineering Part B …, 2020 - liebertpub.com
The obesity epidemic and its associated comorbidities present a looming challenge to
health care delivery throughout the world. Obesity is characterized as a sterile inflammatory …

Advanced gelatin-based vascularization bioinks for extrusion-based bioprinting of vascularized bone equivalents

A Leucht, AC Volz, J Rogal, K Borchers, PJ Kluger - Scientific reports, 2020 - nature.com
Bone tissue is highly vascularized. The crosstalk of vascular and osteogenic cells is not only
responsible for the formation of the strongly divergent tissue types but also for their …

Photocrosslinkable nanocomposite ink for printing strong, biodegradable and bioactive bone graft

Y Yang, Q Zhang, T Xu, H Zhang, M Zhang, L Lu… - Biomaterials, 2020 - Elsevier
Abstract 3D printing is known as a cost-effective technique that shows huge potential in
fabrication of graft substitutes for bone tissue regeneration. However, the tradeoff between …

Evaluation of 3D printed gelatin‐based scaffolds with varying pore size for MSC‐based adipose tissue engineering

L Tytgat, MR Kollert, L Van Damme… - Macromolecular …, 2020 - Wiley Online Library
Adipose tissue engineering aims to provide solutions to patients who require tissue
reconstruction following mastectomies or other soft tissue trauma. Mesenchymal stromal …

Biomaterials for breast reconstruction: Promises, advances, and challenges

M Abdul‐Al, A Zaernia, F Sefat - Journal of Tissue Engineering …, 2020 - Wiley Online Library
Breast reconstruction is the opportunity that provides the chance of having breast after
undergoing surgical removal of the breast tissue due to cancer‐related surgery. However …

Bioprinting predifferentiated adipose-derived mesenchymal stem cell spheroids with methacrylated gelatin ink for adipose tissue engineering

J Colle, P Blondeel, A De Bruyne, S Bochar… - Journal of Materials …, 2020 - Springer
The increasing number of mastectomies results in a greater demand for breast
reconstruction characterized by simplicity and a low complication profile. Reconstructive …

Improvement of a Three-Layered in vitro Skin Model for Topical Application of Irritating Substances

FF Schmidt, S Nowakowski, PJ Kluger - Frontiers in Bioengineering …, 2020 - frontiersin.org
In the field of skin tissue engineering, the development of physiologically relevant in vitro
skin models comprising all skin layers, namely epidermis, dermis, and subcutis, is a great …

Grand challenges in the design and manufacture of vascular self-healing

IPS Qamar, NR Sottos, RS Trask - Multifunctional Materials, 2020 - iopscience.iop.org
This perspective details the grand challenges of designing and manufacturing
multifunctional materials to impart autonomous property recovery. The susceptibility of …

Adipose stem cell‐derived extracellular matrix represents a promising biomaterial by inducing spontaneous formation of prevascular‐like structures by mvECs

S Nellinger, I Schmidt, S Heine… - Biotechnology and …, 2020 - Wiley Online Library
Tissue constructs of physiologically relevant scale require a vascular system to maintain cell
viability. However, in vitro vascularization of engineered tissues is still a major challenge …

Three-dimensional cell printing of gingival fibroblast/acellular dermal matrix/gelatin–sodium alginate scaffolds and their biocompatibility evaluation in vitro

P Liu, Q Li, Q Yang, S Zhang, C Lin, G Zhang, Z Tang - RSC advances, 2020 - pubs.rsc.org
Tissue engineering has emerged as a promising approach for soft tissue regeneration.
Three-dimensional (3D) cell printing showed great potential for producing cell-encapsulated …