Truncated stathmin-2 is a marker of TDP-43 pathology in frontotemporal dementia
M Prudencio, J Humphrey, S Pickles… - The Journal of …, 2020 - Am Soc Clin Investig
No treatment for frontotemporal dementia (FTD), the second most common type of early-
onset dementia, is available, but therapeutics are being investigated to target the 2 main …
onset dementia, is available, but therapeutics are being investigated to target the 2 main …
Consistent gene signature of schizophrenia identified by a novel feature selection strategy from comprehensive sets of transcriptomic data
The etiology of schizophrenia (SCZ) is regarded as one of the most fundamental puzzles in
current medical research, and its diagnosis is limited by the lack of objective molecular …
current medical research, and its diagnosis is limited by the lack of objective molecular …
A genetics perspective on the role of the (neuro) immune system in schizophrenia
R Birnbaum, DR Weinberger - Schizophrenia research, 2020 - Elsevier
The immune system has long been hypothesized to play a role in schizophrenia
pathogenesis based on data from diverse disciplines. Recent reports of the identification of …
pathogenesis based on data from diverse disciplines. Recent reports of the identification of …
A myelin-related transcriptomic profile is shared by Pitt–Hopkins syndrome models and human autism spectrum disorder
Autism spectrum disorder (ASD) is genetically heterogeneous with convergent
symptomatology, suggesting common dysregulated pathways. In this study, we analyzed …
symptomatology, suggesting common dysregulated pathways. In this study, we analyzed …
Profiling gene expression in the human dentate gyrus granule cell layer reveals insights into schizophrenia and its genetic risk
Specific cell populations may have unique contributions to schizophrenia but may be missed
in studies of homogenate tissue. Here laser capture microdissection followed by RNA …
in studies of homogenate tissue. Here laser capture microdissection followed by RNA …
Identification and prioritization of gene sets associated with schizophrenia risk by co-expression network analysis in human brain
Schizophrenia polygenic risk is plausibly manifested by complex transcriptional
dysregulation in the brain, involving networks of co-expressed and functionally related …
dysregulation in the brain, involving networks of co-expressed and functionally related …
Cannabinoid receptor CNR1 expression and DNA methylation in human prefrontal cortex, hippocampus and caudate in brain development and schizophrenia
Beyond being one the most widely used psychoactive drugs in the world, cannabis has
been identified as an environmental risk factor for psychosis. Though the relationship …
been identified as an environmental risk factor for psychosis. Though the relationship …
COVID-19. Pandemic surgery guidance
Based on high quality surgery and scientific data, scientists and surgeons are committed to
protecting patients as well as healthcare staff and hereby provide this Guidance to address …
protecting patients as well as healthcare staff and hereby provide this Guidance to address …
Common gene expression signatures in Parkinson's disease are driven by changes in cell composition
The etiology of Parkinson's disease is largely unknown. Genome-wide transcriptomic
studies in bulk brain tissue have identified several molecular signatures associated with the …
studies in bulk brain tissue have identified several molecular signatures associated with the …
Schizophrenia risk variants influence multiple classes of transcripts of sorting nexin 19 (SNX19)
Genome-wide association studies (GWAS) have identified many genomic loci associated
with risk for schizophrenia, but unambiguous identification of the relationship between …
with risk for schizophrenia, but unambiguous identification of the relationship between …