Identifying new substrates and functions for an old enzyme: calcineurin
J Roy, MS Cyert - Cold Spring Harbor Perspectives in …, 2020 - cshperspectives.cshlp.org
Biological processes are dynamically regulated by signaling networks composed of protein
kinases and phosphatases. Calcineurin, or PP3, is a conserved phosphoserine …
kinases and phosphatases. Calcineurin, or PP3, is a conserved phosphoserine …
Shank3 mutation in a mouse model of autism leads to changes in the S-nitroso-proteome and affects key proteins involved in vesicle release and synaptic function
Mutation in the SHANK3 human gene leads to different neuropsychiatric diseases including
Autism Spectrum Disorder (ASD), intellectual disabilities and Phelan-McDermid syndrome …
Autism Spectrum Disorder (ASD), intellectual disabilities and Phelan-McDermid syndrome …
Selected microRNAs increase synaptic resilience to the damaging binding of the Alzheimer's disease amyloid beta oligomers
O Zolochevska, G Taglialatela - Molecular neurobiology, 2020 - Springer
Alzheimer's disease (AD) is marked by synaptic loss (at early stages) and neuronal death (at
late stages). Amyloid beta (Aβ) and tau oligomers can target and disrupt synapses thus …
late stages). Amyloid beta (Aβ) and tau oligomers can target and disrupt synapses thus …
Neurogranin stimulates Ca2+/calmodulin-dependent kinase II by suppressing calcineurin activity at specific calcium spike frequencies
L Li, M Lai, S Cole, N Le Novère… - PLoS computational …, 2020 - journals.plos.org
Calmodulin sits at the center of molecular mechanisms underlying learning and memory. Its
complex and sometimes opposite influences, mediated via the binding to various proteins …
complex and sometimes opposite influences, mediated via the binding to various proteins …
Destruction of ERP responses to deviance in an auditory oddball paradigm in amyloid infusion mice with memory deficits
The amyloid-β (Aβ) oligomer is considered one of the major pathogens responsible for
neuronal and synaptic loss in Alzheimer's disease (AD) brains. Although the neurotoxic …
neuronal and synaptic loss in Alzheimer's disease (AD) brains. Although the neurotoxic …
Avaliação dos efeitos de um inibidor da calcineurina em modelos experimentais da doença de Alzheimer
GF Gomes - 2020 - repositorio.ufmg.br
RESUMO A doença de Alzheimer (DA) é a principal causa de demência no mundo,
justificando o melhor entendimento de sua fisiopatologia e a busca por novos alvos …
justificando o melhor entendimento de sua fisiopatologia e a busca por novos alvos …