ATP-binding cassette (ABC) transporters constitute one of the largest and most ancient
protein superfamilies found in all living organisms. They function as molecular machines by …

Vitamins B9 (folate) and B12 are essential water-soluble vitamins that play a crucial role in
the maintenance of one-carbon metabolism: a set of interconnected biochemical pathways …

Cobalamin (Cbl), also known as vitamin B12, is an indispensable water-soluble molecule.
As far as it is known at present, its function is restricted to cofactorial activity for only two …

Background More teats are necessary for sows to nurse larger litters to provide immunity
and nutrient for piglets prior to weaning. Previous studies have reported the strong effect of …

Vitamin B12 is an essential micronutrient that functions in two metabolic pathways: the
canonical propionate breakdown pathway and the methionine/S-adenosylmethionine …

ABC transporters fulfill diverse physiological functions in different cellular localizations
ranging from the plasma membrane to intracellular membranous compartments. Several …

Mutations in CLN3 are a cause of juvenile neuronal ceroid lipofuscinosis (JNCL), also
known as Batten disease. Clinical manifestations include cognitive regression, progressive …

Disorders caused by defects in lysosomal membrane transporters form a distinct subgroup
of lysosomal storage disorders (LSDs). To date, defects in only 10 lysosomal membrane …

Vitamin B12 also known as cobalamin is a cobalt-containing corrin ring cofactor required for
two enzymes in higher animals, methionine synthase and L-methylmalonyl-Co-A mutase. It …

Bacterial membrane proteins of the SbmA/BacA family are multi‐solute transporters that
mediate the uptake of structurally diverse hydrophilic molecules, including aminoglycoside …