Ethnopharmacological relevance Evodia rutaecarpa, a well-known herb medicine in China,
is extensively applied in traditional Chinese medicine (TCM). The plant has the effects of …

A new series of styrylquinolines was designed and synthesized as anticancer agents and
tubulin polymerization inhibitors. The in vitro anticancer activity of the synthesized quinolines …

A silver-catalyzed cascade cyclization reaction of isocyanides with sulfoxonium ylides has
been developed for the first time. This reaction provides a new and efficient method for the …

A great challenge in multi-targeting drug discovery is to identify drug-like lead compounds
with therapeutic advantages over single target inhibitors and drug combinations. Inspired by …

A concise, one-step route to produce 3, 3′-diindolylmethanes (DIMs) from simple indoles
and ketones or aldehydes is reported. The key step is the ready formation of indole …

Clinical use of phosphodiesterase-5 (PDE5) inhibitors is limited by several side effects due
to weak isoform selectivity. Herein, a unique allosteric pocket of PDE5 is identified by …

Autophagy and NLRP3 inflammasome were associated with the process of colitis. Drugs
targeting NLRP3 inflammasome and autophagy to treat colitis are absent, and they are …

In order to improve the antitumor potency of the natural product evodiamine, novel boron-
containing evodiamine derivatives were designed by incorporating boronic acid and …

A Simple, convenient and highly efficient I2‐catalysed approach has been unfolded towards
the synthesis of highly fluorescent β‐carboline C‐1 (3)‐tethered thiazolo [4, 5‐c] carbazoles …

Bisindolylmethanes (3, 3'-BIMs) compounds are important indole alkyloads and their units
are widely found in various natural products, functional materials and synthetic …