Autoimmune diseases are a result of the immune system being misdirected toward its host
and have major and increasing unmet clinical needs. In general, present therapies are …

The high-fat, low-carbohydrate ketogenic diet (KD) is an established treatment for drug-
resistant epilepsy with a proven efficacy. The KD is being explored for Febrile Infection …

Aging causes a functional decline in tissues throughout the body that may be delayed by
caloric restriction (CR). However, the cellular profiles and signatures of aging, as well as …

The concept that dietary changes could improve the response to cancer therapy is extremely
attractive to many patients, who are highly motivated to take control of at least some aspect …

Non-alcoholic fatty liver disease (NAFLD) is a major health issue worldwide, frequently
associated with obesity and type 2 diabetes. Steatosis is the initial stage of the disease …

Emerging evidence suggests that the effect of dietary intake on human health and disease is
linked to both the immune system and the microbiota. Yet, we lack an integrated mechanistic …

Over the past 10 years, the field of immunometabolism made great strides to unveil the
crucial role of intracellular metabolism in regulating immune cell function. Emerging insights …

Integrated immunometabolic responses link dietary intake, energy utilization, and storage to
immune regulation of tissue function and is therefore essential for the maintenance and …

Background Most cancer cells exhibit increased glycolysis and use this metabolic pathway
cell growth and proliferation. Targeting cancer cells' metabolism is a promising strategy in …

Atherosclerotic lesions progress through the continued recruitment of circulating blood
monocytes that differentiate into macrophages within plaque. Lesion-associated …