Copy number variations (CNVs) of the human 16p11. 2 genetic locus are associated with a
range of neurodevelopmental disorders, including autism spectrum disorder, intellectual …

Neuropsychiatric disorders are complex disorders characterized by heterogeneous genetic
variations, variable symptoms, and widespread changes in anatomical pathology. In the …

The hippocampus is important for memory formation and is severely affected in the brain
with Alzheimer disease (AD). Our understanding of early pathogenic processes occurring in …

Maternal immune activation increases the risk of neurodevelopmental disorders. Elevated
cytokines, such as interferon-γ (IFN-γ), in offspring's brains play a central role. IFN-γ …

Abstract Background The Xp22. 11 locus that encompasses PTCHD1, DDX53, and the long
noncoding RNA PTCHD1-AS is frequently disrupted in male subjects with autism spectrum …

Autism spectrum disorder (ASD) is a neurodevelopmental disorder diagnosed in 1 in 59
children in the United States. 1 ASD is characterized by heterogeneous symptom profiles …

Microdeletions and microduplications of the 16p11. 2 chromosomal locus are associated
with syndromic neurodevelopmental disorders and reciprocal physiological conditions such …

Despite decades of study, elucidation of the underlying etiology of complex developmental
disorders such as autism spectrum disorder (ASD), schizophrenia (SCZ), intellectual …

Induced pluripotent stem cells (iPSCs) hold promise to revolutionize studies of intracellular
transport in live human neurons and to shed new light on the role of dysfunctional transport …

Brain disorders, from neurodegenerative to psychiatric disorders, are among the most
challenging conditions to study because of the intricate nature of the human brain and the …