Most neurodegenerative diseases are characterized by the intracellular or extracellular
aggregation of misfolded proteins such as amyloid-β and tau in Alzheimer disease, α …

Accumulation of misfolded and aggregated forms of tau protein in the brain is a
neuropathological hallmark of tauopathies, such as Alzheimer's disease and frontotemporal …

Background Many lines of evidence suggest that accumulation of aggregated alpha-
synuclein (αSYN) in the Parkinson's disease (PD) brain causes infiltration of T cells …

Alpha-synuclein (α-syn) is localized in cellular organelles of most neurons, but many of its
physiological functions are only partially understood. α-syn accumulation is associated with …

Aberrant accumulation of misfolded proteins into amyloid deposits is a hallmark in many age-
related neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's …

The pathologic hallmark of Parkinson's disease is the accumulation of α-synuclein-
containing Lewy bodies/neurites almost exclusively in neurons, and rarely in glial cells …

The intricate relationships between innate immunity and brain diseases raise increased
interest across the wide spectrum of neurodegenerative and neuropsychiatric disorders …

Numerous lines of evidence indicate an association between sustained inflammation and
Parkinson's disease, but whether increased inflammation is a cause or consequence of …

Alpha-synuclein (aSyn) was identified as the main component of inclusions that define
synucleinopathies more than 20 years ago. Since then, aSyn has been extensively studied …

The progressive accumulation and spread of misfolded tau protein in the nervous system is
the hallmark of tauopathies, progressive neurodegenerative diseases with only symptomatic …