Chemokines, which are basic proteins that exert their effects via G protein-coupled receptors
and a subset of the cytokine family, are mediators deeply involved in leukocyte migration …

Gastrointestinal microbiota and immune cells interact closely and display regional
specificity; however, little is known about how these communities differ with location. Here …

The chemokine CCL20 is broadly produced by endothelial cells in the liver, the lung, in
lymph nodes and mucosal lymphoid tissues, and recruits CCR6 expressing leukocytes …

The CC chemokine receptor 6 (CCR6) and its sole chemokine ligand, CCL20, are an
intriguing pair that have been implicated in a growing number of inflammatory, autoimmune …

Background The activation of the EGFR/Ras-signalling pathway in tumour cells induces a
distinct chemokine repertoire, which in turn modulates the tumour microenvironment …

The chemokine receptor CCR9 and its only known ligand CCL25 play an important role in
gut inflammation and autoimmune colitis. The function of CCR9‐CCL25 in the migration of …

Over 90% of pathogens of medical importance invade the organism through mucosal
surfaces, which makes it urgent to develop safe and effective mucosal vaccines and …

Combined radioimmunotherapy is currently being investigated to treat patients with cancer.
Anti-programmed cell death-1 (PD-1) immunotherapy offers the prospect of long-term …

The effective antigen (Ag) uptake by microfold cells (M-cells) is important for the induction of
an efficient mucosal immune responses. Here, we show that 10-hydroxydecanoic acid (10 …

Memory B cells develop after mucosal vaccination, but little is known about how and where
these cells are induced and maintained for long periods of time. The gut immune system is …