Due to the limit of available treatments and the emergence of drug resistance in the clinic,
invasive fungal infections are an intractable problem with high morbidity and mortality. The …

Herein, novel three series of benzimidazole scaffold bearing hydrazone, 1, 2, 4-triazole and
1, 3, 4-oxadiazole moieties 1-3, 4a-j, 6a-c and 7 derivatives were designed, synthesized and …

Background Esculentosides and related phytolaccosides form a group of oleanene-type
saponins isolated from plants of the Phytolaccaceae family, essentially Phytolacca …

Background Candida albicans is the most prevalent opportunistic fungal pathogen.
Development of antifungals with novel targets is necessary for limitations of current …

The enantiomers (R)-(+)-β-citronellol and (S)-(−)-β-citronellol are present in many medicinal
plants, but little is understood about their bioactivity against Candida yeasts. This study …

Aim The purpose of this study was to uncover insights into the mechanism of action of the 8‐
hydroxyquinoline derivatives PH151 and PH153. In addition, with the future perspective of …

Sucrose induces flavonoid accumulation in plants as a defense mechanism against various
stresses. However, the relationship between the biosynthesis of flavonoids as secondary …

Cryptococcus neoformans is a yeast fungus, which causes cryptococcosis, triggered by
basidiospore inhalation and consequent dissemination to the central nervous system. In this …

Nosocomial infections are an important cause of morbi-mortality worldwide. The increase in
the rate of resistance to conventional drugs in these microorganisms has stimulated the …

Background Fungal infections are highly prevalent and are responsible for high rates of
morbidity and mortality. In this context, the search for new treatment alternatives is very …