Clinical potential of a rationally engineered enzyme for treatment of cocaine dependence: Long-lasting blocking of the psychostimulant, discriminative stimulus, and …
It is a grand challenge to develop a truly effective treatment of substance use disorder
(SUD), particularly for cocaine and other drugs without an FDA-approved treatment …
(SUD), particularly for cocaine and other drugs without an FDA-approved treatment …
Structure-based design and discovery of a long-acting cocaine hydrolase mutant with improved binding affinity to neonatal Fc receptor for treatment of cocaine abuse
Despite decades of efforts to develop a pharmacotherapy for cocaine abuse treatment, there
is still no FDA-approved treatment of diseases associated with this commonly abused drug …
is still no FDA-approved treatment of diseases associated with this commonly abused drug …
Reengineering of albumin-fused cocaine hydrolase CocH1 (TV-1380) to prolong its biological half-life
Therapeutic treatment of cocaine toxicity or addiction is a grand medical challenge. As a
promising therapeutic strategy for treatment of cocaine toxicity and addiction to develop a …
promising therapeutic strategy for treatment of cocaine toxicity and addiction to develop a …
Catalytic activities of cocaine hydrolases against the most toxic cocaine metabolite norcocaethylene
A majority of cocaine users also consume alcohol. The concurrent use of cocaine and
alcohol produces the pharmacologically active metabolites cocaethylene and …
alcohol produces the pharmacologically active metabolites cocaethylene and …
Effects of cebranopadol on cocaine-induced hyperactivity and cocaine pharmacokinetics in rats
Cebranopadol is known as a highly potent analgesic. Recent studies also demonstrated that
administration of cebranopadol significantly decreased cocaine self-administration and …
administration of cebranopadol significantly decreased cocaine self-administration and …
Cebranopadol reduces cocaine self-administration in male rats: Dose, treatment and safety consideration
As a novel first-in-class potent analgesic acting as an agonist of multiple opioid receptors,
cebranopadol showed high efficacy and good tolerability in a broad range of preclinical …
cebranopadol showed high efficacy and good tolerability in a broad range of preclinical …
A plant-derived cocaine hydrolase prevents cocaine overdose lethality and attenuates cocaine-induced drug seeking behavior
KE Larrimore, L Kannan, RP Kendle, T Jamal… - Progress in Neuro …, 2020 - Elsevier
Cocaine use disorders include short-term and acute pathologies (eg overdose) and long-
term and chronic disorders (eg intractable addiction and post-abstinence relapse). There is …
term and chronic disorders (eg intractable addiction and post-abstinence relapse). There is …