In recent years, the continuous occurrence of multi-drug resistance in the clinic has made
people pay more attention to the transporter. Changes in the expression and activity of …

One of the major problems being faced by researchers and clinicians in leukemic treatment
is the development of multidrug resistance (MDR) which restrict the action of several tyrosine …

Organic cation transporters (OCT) 1, 2 and 3 and novel organic cation transporters (OCTN) 1
and 2 of the solute carrier 22 (SLC22) family are involved in the cellular transport of …

Cancer remains one of the highest leading causes of morbidity and mortality worldwide.
Anthracyclines, specifically Doxorubicin (DOX), have been used for the past three decades …

Cisplatin (DDP) is one of the first‐line chemotherapeutic agents for non‐small cell lung
cancer (NSCLC). However, repeated use of cisplatin in clinical practice often induces …

Simple Summary Multidrug resistance and infiltration/metastasis of cancer are two major
issues that must be overcome during chemotherapy. Efflux transporters, such as P …

Multidrug resistance due to facilitated drug efflux mediated by ATP‐binding cassette (ABC)
transporters is a main cause for failure of cancer therapy. Genetic polymorphisms in ABC …

Detoxification in hepatocytes is a strictly controlled process, in which the governed action of
membrane transporters involved in the uptake and efflux of potentially dangerous molecules …

Aim Drug resistance is an intractable issue urgently needed to be overcome for improving
efficiency of antiepileptic drugs in treating refractory epilepsy. microRNAs (miRNAs) have …

The kidney is essential for the physiological functions of the body. When exposed to high
concentrations of toxins, these may induce the toxicity of the kidney (kidney injury), leading …