A neuroscientist's guide to transgenic mice and other genetic tools

S Navabpour, JL Kwapis, TJ Jarome - Neuroscience & Biobehavioral …, 2020 - Elsevier
The past decade has produced an explosion in the number and variety of genetic tools
available to neuroscientists, resulting in an unprecedented ability to precisely manipulate …

Chemogenetics a robust approach to pharmacology and gene therapy

O Keifer, K Kambara, A Lau, S Makinson… - Biochemical …, 2020 - Elsevier
Modern developments in organic chemistry, molecular biology, virology, and genetics have
opened new, exciting possibilities to better understand physiology and to create innovative …

[HTML][HTML] Nesfatin-1 decreases the motivational and rewarding value of food

R Dore, R Krotenko, JP Reising, L Murru… - …, 2020 - nature.com
Homeostatic and hedonic pathways distinctly interact to control food intake. Dysregulations
of circuitries controlling hedonic feeding may disrupt homeostatic mechanisms and lead to …

Chemogenetic inhibition of dopaminergic projections to the nucleus accumbens has sexually dimorphic effects in the rat gambling task.

TJ Hynes, JMM Ferland, TL Feng… - Behavioral …, 2020 - psycnet.apa.org
Women and men can differ in their propensity to take risks and develop impulse control and
addiction disorders. Sexual dimorphisms in behavioral control by the mesolimbic …

Pituitary adenylate cyclase-activating polypeptide excites proopiomelanocortin neurons: implications for the regulation of energy homeostasis

R Chang, J Hernandez, C Gastelum, K Guadagno… - …, 2020 - karger.com
Objective: We examined whether pituitary adenylate cyclase-activating polypeptide
(PACAP) excites proopiomelanocortin (POMC) neurons via PAC1 receptor mediation and …

It takes a neural village: Circuit-based approaches for estrogenic regulation of episodic memory

MR Schwabe, LR Taxier, KM Frick - Frontiers in neuroendocrinology, 2020 - Elsevier
Cognitive behaviors, such as episodic memory formation, are complex processes involving
coordinated activity in multiple brain regions. However, much of the research on hormonal …

[HTML][HTML] Canine adenovirus 2: A natural choice for brain circuit dissection

A Lavoie, B Liu - Frontiers in Molecular Neuroscience, 2020 - frontiersin.org
Canine adenovirus-2 (CAV) is a canine pathogen that has been used in a variety of
applications, from vaccines against more infectious strains of CAV to treatments for …

Gq DREADD activation of CaMKIIa MnPO neurons stimulates nitric oxide activity

AB Marciante, GE Farmer… - Journal of …, 2020 - journals.physiology.org
Designer receptors exclusively activated by designer drugs (DREADDs) modify cellular
activity following administration of the exogenous ligand clozapine-N-oxide (CNO) …

Combining designer receptors exclusively activated by designer drugs and neuroimaging in experimental models: A powerful approach towards neurotheranostic …

LM Peeters, S Missault, AJ Keliris… - British Journal of …, 2020 - Wiley Online Library
The combination of chemogenetics targeting specific brain cell populations with in vivo
imaging techniques provides scientists with a powerful new tool to study functional neural …

[PDF][PDF] Combining DREADDs and neuroimaging in experimental models: a powerful approach towards neurotheranostic applications

LM Peeters - Unraveling the interplay of brain networks …, 2020 - repository.uantwerpen.be
The combination of chemogenetics targeting specific brain cell populations with invivo
imaging techniques provides scientists with a powerful new tool to study functional neural …