Advances in pluripotent stem cells: history, mechanisms, technologies, and applications

G Liu, BT David, M Trawczynski, RG Fessler - Stem cell reviews and …, 2020 - Springer
Over the past 20 years, and particularly in the last decade, significant developmental
milestones have driven basic, translational, and clinical advances in the field of stem cell …

Zero-order drug delivery: State of the art and future prospects

ML Laracuente, HY Marina, KJ McHugh - Journal of Controlled Release, 2020 - Elsevier
Pharmaceutical drugs are an important part of the global healthcare system, with some
estimates suggesting over 50% of the world's population takes at least one medication per …

Nanotechnology: a promising approach for delivery of neuroprotective drugs

S Naqvi, A Panghal, SJS Flora - Frontiers in Neuroscience, 2020 - frontiersin.org
Central nervous system (CNS) disorders especially neurodegenerative disorders are the
major challenge for public health and demand the great attention of researchers to protect …

Intranasal delivery of nanoformulations: a potential way of treatment for neurological disorders

SU Islam, A Shehzad, MB Ahmed, YS Lee - Molecules, 2020 - mdpi.com
Although the global prevalence of neurological disorders such as Parkinson's disease,
Alzheimer's disease, glioblastoma, epilepsy, and multiple sclerosis is steadily increasing …

Magnesium hydroxide-incorporated PLGA composite attenuates inflammation and promotes BMP2-induced bone formation in spinal fusion

TM Bedair, CK Lee, DS Kim, SW Baek… - Journal of tissue …, 2020 - journals.sagepub.com
Spinal fusion has become a common surgical technique to join two or more vertebrae to
stabilize a damaged spine; however, the rate of pseudarthrosis (failure of fusion) is still high …

Colon specific enzyme responsive oligoester crosslinked dextran nanoparticles for controlled release of 5-fluorouracil

M Abid, M Naveed, I Azeem, A Faisal, MF Nazar… - International Journal of …, 2020 - Elsevier
Targeting bioactives selectively to diseased sites is one of the most challenging aspects of
cancer therapy. Herein, fabrication of colonic enzyme-responsive dextran based oligoester …

Production of drug-releasing biodegradable microporous scaffold impregnated with gemcitabine using a CO2 foaming process

I Álvarez, C Gutiérrez, JF Rodriguez, A De Lucas… - Journal of CO2 …, 2020 - Elsevier
The use of supercritical fluids technology, in particular the use of CO2, is an important
advantage over other production techniques of controlled release systems. The …

Eudragit®-S100 Coated PLGA Nanoparticles for Colon Targeting of Etoricoxib: Optimization and Pharmacokinetic Assessments in Healthy Human Volunteers

E El-Maghawry, MI Tadros, SA Elkheshen… - International Journal …, 2020 - Taylor & Francis
Aim Etoricoxib is a selective inhibitor of COX-2 enzyme. It is proposed as a potent anti-
inflammatory drug intended for the control of irritable bowel syndrome. The current work …

Experimental Studies and Modeling of the Degradation Process of Poly(Lactic-co-Glycolic Acid) Microspheres for Sustained Protein Release

PA Netti, M Biondi, M Frigione - Polymers, 2020 - mdpi.com
In this study, poly (lactic-co-glycolic acid) microspheres (PLGA MS) for controlled protein
release by double emulsion-solvent evaporation were produced and characterized for their …

Physiologically relevant mechanics of biodegradable polyester nanoparticles

N Alsharif, B Eshaghi, BM Reinhard, KA Brown - Nano letters, 2020 - ACS Publications
Despite the extensive use of biodegradable polyester nanoparticles for drug delivery, and
reports of the strong influence of nanoparticle mechanics on nano− bio interactions, there is …