Schizophrenia and influenza at the centenary of the 1918-1919 Spanish influenza pandemic: mechanisms of psychosis risk

AP Kępińska, CO Iyegbe, AC Vernon, R Yolken… - Frontiers in …, 2020 - frontiersin.org
Associations between influenza infection and psychosis have been reported since the
eighteenth century, with acute “psychoses of influenza” documented during multiple …

Role of inflammation in the pathogenesis of schizophrenia: A review of the evidence, proposed mechanisms and implications for treatment

D Mongan, M Ramesar, M Föcking… - Early intervention in …, 2020 - Wiley Online Library
Aim Over the past several decades, there has been a growing research interest in the role of
inflammation in the pathogenesis of schizophrenia. This review aims to summarize evidence …

A computational tool (H-MAGMA) for improved prediction of brain-disorder risk genes by incorporating brain chromatin interaction profiles

NYA Sey, B Hu, W Mah, H Fauni, JC McAfee… - Nature …, 2020 - nature.com
Most risk variants for brain disorders identified by genome-wide association studies reside in
the noncoding genome, which makes deciphering biological mechanisms difficult. A …

Exome sequencing identifies rare coding variants in 10 genes which confer substantial risk for schizophrenia

T Singh, BM Neale, MJ Daly - MedRxiv, 2020 - medrxiv.org
By meta-analyzing the whole-exomes of 24,248 cases and 97,322 controls, we implicate
ultra-rare coding variants (URVs) in ten genes as conferring substantial risk for …

The genetics of the mood disorder spectrum: genome-wide association analyses of more than 185,000 cases and 439,000 controls

JRI Coleman, HA Gaspar, J Bryois, EM Byrne… - Biological …, 2020 - Elsevier
Background Mood disorders (including major depressive disorder and bipolar disorder)
affect 10% to 20% of the population. They range from brief, mild episodes to severe …

[HTML][HTML] Whole-genome and RNA sequencing reveal variation and transcriptomic coordination in the developing human prefrontal cortex

DM Werling, S Pochareddy, J Choi, JY An, B Sheppard… - Cell reports, 2020 - cell.com
Gene expression levels vary across developmental stage, cell type, and region in the brain.
Genomic variants also contribute to the variation in expression, and some neuropsychiatric …

Meta‐analysis of total and differential white blood cell counts in schizophrenia

AJ Jackson, BJ Miller - Acta Psychiatrica Scandinavica, 2020 - Wiley Online Library
Objective Schizophrenia is associated with alterations in blood inflammatory markers,
including cytokines. Total white blood cell (WBC) count is a marker of low‐grade …

Bivariate genome-wide association analyses of the broad depression phenotype combined with major depressive disorder, bipolar disorder or schizophrenia reveal …

AT Amare, A Vaez, YH Hsu, N Direk, Z Kamali… - Molecular …, 2020 - nature.com
Although a genetic basis of depression has been well established in twin studies,
identification of genome-wide significant loci has been difficult. We hypothesized that …

Persistent psychotic symptoms following COVID-19 infection

ST Lim, B Janaway, H Costello, A Trip, G Price - BJPsych open, 2020 - cambridge.org
To date, there have been no detailed reports of patients developing persistent psychotic
symptoms following Coronavirus disease 2019 (COVID-19) infection. There have been …

Depression and obesity: analysis of common biomarkers

W Milano, P Ambrosio, F Carizzone, V De Biasio… - Diseases, 2020 - mdpi.com
Depression and obesity are very common pathologies. Both cause significant problems of
both morbidity and mortality and have decisive impacts not only on the health and well …