Schizophrenia and influenza at the centenary of the 1918-1919 Spanish influenza pandemic: mechanisms of psychosis risk
AP Kępińska, CO Iyegbe, AC Vernon, R Yolken… - Frontiers in …, 2020 - frontiersin.org
Associations between influenza infection and psychosis have been reported since the
eighteenth century, with acute “psychoses of influenza” documented during multiple …
eighteenth century, with acute “psychoses of influenza” documented during multiple …
Role of inflammation in the pathogenesis of schizophrenia: A review of the evidence, proposed mechanisms and implications for treatment
Aim Over the past several decades, there has been a growing research interest in the role of
inflammation in the pathogenesis of schizophrenia. This review aims to summarize evidence …
inflammation in the pathogenesis of schizophrenia. This review aims to summarize evidence …
A computational tool (H-MAGMA) for improved prediction of brain-disorder risk genes by incorporating brain chromatin interaction profiles
NYA Sey, B Hu, W Mah, H Fauni, JC McAfee… - Nature …, 2020 - nature.com
Most risk variants for brain disorders identified by genome-wide association studies reside in
the noncoding genome, which makes deciphering biological mechanisms difficult. A …
the noncoding genome, which makes deciphering biological mechanisms difficult. A …
Exome sequencing identifies rare coding variants in 10 genes which confer substantial risk for schizophrenia
By meta-analyzing the whole-exomes of 24,248 cases and 97,322 controls, we implicate
ultra-rare coding variants (URVs) in ten genes as conferring substantial risk for …
ultra-rare coding variants (URVs) in ten genes as conferring substantial risk for …
The genetics of the mood disorder spectrum: genome-wide association analyses of more than 185,000 cases and 439,000 controls
JRI Coleman, HA Gaspar, J Bryois, EM Byrne… - Biological …, 2020 - Elsevier
Background Mood disorders (including major depressive disorder and bipolar disorder)
affect 10% to 20% of the population. They range from brief, mild episodes to severe …
affect 10% to 20% of the population. They range from brief, mild episodes to severe …
[HTML][HTML] Whole-genome and RNA sequencing reveal variation and transcriptomic coordination in the developing human prefrontal cortex
Gene expression levels vary across developmental stage, cell type, and region in the brain.
Genomic variants also contribute to the variation in expression, and some neuropsychiatric …
Genomic variants also contribute to the variation in expression, and some neuropsychiatric …
Meta‐analysis of total and differential white blood cell counts in schizophrenia
AJ Jackson, BJ Miller - Acta Psychiatrica Scandinavica, 2020 - Wiley Online Library
Objective Schizophrenia is associated with alterations in blood inflammatory markers,
including cytokines. Total white blood cell (WBC) count is a marker of low‐grade …
including cytokines. Total white blood cell (WBC) count is a marker of low‐grade …
Bivariate genome-wide association analyses of the broad depression phenotype combined with major depressive disorder, bipolar disorder or schizophrenia reveal …
Although a genetic basis of depression has been well established in twin studies,
identification of genome-wide significant loci has been difficult. We hypothesized that …
identification of genome-wide significant loci has been difficult. We hypothesized that …
Persistent psychotic symptoms following COVID-19 infection
To date, there have been no detailed reports of patients developing persistent psychotic
symptoms following Coronavirus disease 2019 (COVID-19) infection. There have been …
symptoms following Coronavirus disease 2019 (COVID-19) infection. There have been …
Depression and obesity: analysis of common biomarkers
W Milano, P Ambrosio, F Carizzone, V De Biasio… - Diseases, 2020 - mdpi.com
Depression and obesity are very common pathologies. Both cause significant problems of
both morbidity and mortality and have decisive impacts not only on the health and well …
both morbidity and mortality and have decisive impacts not only on the health and well …