Diagnosis and treatment of Parkinson disease: a review

MJ Armstrong, MS Okun - Jama, 2020 - jamanetwork.com
Importance Parkinson disease is the most common form of parkinsonism, a group of
neurological disorders with Parkinson disease–like movement problems such as rigidity …

The genetic architecture of Parkinson's disease

C Blauwendraat, MA Nalls, AB Singleton - The Lancet Neurology, 2020 - thelancet.com
Parkinson's disease is a complex neurodegenerative disorder for which both rare and
common genetic variants contribute to disease risk, onset, and progression. Mutations in …

[HTML][HTML] In vitro Models of Neurodegenerative Diseases

A Slanzi, G Iannoto, B Rossi, E Zenaro… - Frontiers in cell and …, 2020 - frontiersin.org
Neurodegenerative diseases are progressive degenerative conditions characterized by the
functional deterioration and ultimate loss of neurons. These incurable and debilitating …

[HTML][HTML] The pathology of Parkinson's disease and potential benefit of dietary polyphenols

S Aryal, T Skinner, B Bridges, JT Weber - Molecules, 2020 - mdpi.com
Parkinson's disease (PD) is a progressive neurodegenerative disorder that is characterized
by a loss of dopaminergic neurons, leading to bradykinesia, rigidity, tremor at rest, and …

[HTML][HTML] Lipopolysaccharide animal models of Parkinson's disease: Recent progress and relevance to clinical disease

I Deng, F Corrigan, G Zhai, XF Zhou… - Brain, behavior, & …, 2020 - Elsevier
Parkinson's disease (PD) is one of the most common neurodegenerative movement
disorders which is characterised neuropathologically by progressive loss of dopaminergic …

[HTML][HTML] Behavioral tests in neurotoxin-induced animal models of Parkinson's disease

EM Prasad, SY Hung - Antioxidants, 2020 - mdpi.com
Currently, neurodegenerative diseases are a major cause of disability around the world.
Parkinson's disease (PD) is the second-leading cause of neurodegenerative disorder after …

[HTML][HTML] Insights into the effects of mesenchymal stem cell-derived secretome in Parkinson's disease

M d'Angelo, A Cimini, V Castelli - International Journal of Molecular …, 2020 - mdpi.com
Mesenchymal stem cell (MSC)-derived secretome demonstrated therapeutic effects like
those reported after MSCs transplantation. MSC-derived secretome may avoid various side …

Neuroinflammatory responses and Parkinson'disease: pathogenic mechanisms and therapeutic targets

L Yang, K Mao, H Yu, J Chen - Journal of Neuroimmune Pharmacology, 2020 - Springer
Parkinson's disease (PD) is the second most common age-related neurodegenerative
disorders of the central nervous system, which mainly impairs the motor system. However …

[HTML][HTML] LRRK2 phosphorylation, more than an epiphenomenon

A Marchand, M Drouyer, A Sarchione… - Frontiers in …, 2020 - frontiersin.org
Mutations in the Leucine Rich Repeat Kinase 2 (LRRK2) gene are linked to autosomal
dominant Parkinson's disease (PD), and genetic variations at the LRRK2 locus are …

[HTML][HTML] Gait progression over 6 years in Parkinson's disease: Effects of age, medication, and pathology

J Wilson, L Alcock, AJ Yarnall, S Lord… - Frontiers in aging …, 2020 - frontiersin.org
Background: Gait disturbance is an early, cardinal feature of Parkinson's disease (PD)
associated with falls and reduced physical activity. Progression of gait impairment in …