[HTML][HTML] RIG-I-like receptors: their regulation and roles in RNA sensing
J Rehwinkel, MU Gack - Nature Reviews Immunology, 2020 - nature.com
Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are key sensors of virus
infection, mediating the transcriptional induction of type I interferons and other genes that …
infection, mediating the transcriptional induction of type I interferons and other genes that …
The role of astrocytes in CNS inflammation
F Giovannoni, FJ Quintana - Trends in immunology, 2020 - cell.com
Astrocytes are the most abundant cell type in the central nervous system (CNS), performing
complex functions in health and disease. It is now clear that multiple astrocyte subsets or …
complex functions in health and disease. It is now clear that multiple astrocyte subsets or …
Evasion of type I interferon by SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication and host
immune response determine coronavirus disease 2019 (COVID-19), but studies evaluating …
immune response determine coronavirus disease 2019 (COVID-19), but studies evaluating …
[HTML][HTML] SARS-CoV-2 disrupts splicing, translation, and protein trafficking to suppress host defenses
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a recently identified
coronavirus that causes the respiratory disease known as coronavirus disease 2019 (COVID …
coronavirus that causes the respiratory disease known as coronavirus disease 2019 (COVID …
Toll-like receptors and the control of immunity
KA Fitzgerald, JC Kagan - Cell, 2020 - cell.com
The study of innate immunity and its link to inflammation and host defense encompasses
diverse areas of biology, ranging from genetics and biophysics to signal transduction and …
diverse areas of biology, ranging from genetics and biophysics to signal transduction and …
The regulation of the ZBP1‐NLRP3 inflammasome and its implications in pyroptosis, apoptosis, and necroptosis (PANoptosis)
M Zheng, TD Kanneganti - Immunological reviews, 2020 - Wiley Online Library
ZBP1 has been characterized as a critical innate immune sensor of not only viral RNA
products but also endogenous nucleic acid ligands. ZBP1 sensing of the Z‐RNA produced …
products but also endogenous nucleic acid ligands. ZBP1 sensing of the Z‐RNA produced …
Type III interferons disrupt the lung epithelial barrier upon viral recognition
Viral infections of the lower respiratory tract are a leading cause of mortality. Mounting
evidence indicates that most severe cases are characterized by aberrant immune responses …
evidence indicates that most severe cases are characterized by aberrant immune responses …
[HTML][HTML] SARS-CoV-2, the autoimmune virus
G Halpert, Y Shoenfeld - Autoimmunity reviews, 2020 - ncbi.nlm.nih.gov
Increasing evidence accumulated from the past year on the outbreak of corona virus disease
2019 (COVID-19) pandemic, suggesting a strong association between the severe acute …
2019 (COVID-19) pandemic, suggesting a strong association between the severe acute …
SARS-CoV-2 nucleocapsid protein interacts with RIG-I and represses RIG-mediated IFN-β production
K Chen, F Xiao, D Hu, W Ge, M Tian, W Wang, P Pan… - Viruses, 2020 - mdpi.com
SARS-CoV-2 is highly pathogenic in humans and poses a great threat to public health
worldwide. Clinical data shows a disturbed type I interferon (IFN) response during the virus …
worldwide. Clinical data shows a disturbed type I interferon (IFN) response during the virus …
The function and clinical application of extracellular vesicles in innate immune regulation
The innate immune system plays a crucial role in the host defense against viral and
microbial infection. Exosomes constitute a subset of extracellular vesicles (EVs) that can be …
microbial infection. Exosomes constitute a subset of extracellular vesicles (EVs) that can be …