Hepatocellular carcinoma (HCC) is one of the most prevalent and fatal digestive tumors.
Treatment for this disease has been constraint by heterogeneity of this group of tumors …

Hepatocellular carcinoma (HCC) is one of the most severe diseases worldwide. For the
different stages of HCC, there are different clinical treatment strategies, such as surgical …

Hepatocellular carcinoma (HCC), is the sixth most frequent form of cancer and leads to the
fourth highest number of deaths each year. HCC results from a combination of …

为规范肝胆系统原发恶性肿瘤相关分子标志物在临床诊断, 疗效评估及预后预测等方面的应用,
本共识分别从外周血及组织学水平, 针对近年来研究结果较为明确的肝胆肿瘤相关蛋白质 …

Abstract Lessons Learned The combination of trametinib and sorafenib has an acceptable
safety profile, albeit at doses lower than approved for monotherapy. Maximum tolerated …

Highlights•Synthetic lethality defines a molecular framework to enhance the targeting of
cancer vulnerabilities.•The metabolic synthetic lethality focuses on metabolic enzymes or …

Purpose A variety of targeted drug were developed and proved effective and safe in clinical
trials. Our study aims to compare the efficacies and safety of different targeted drugs in …

Upregulation of the RAS-RAF-MEK-ERK-MAPK pathway is involved in the development of
several human tumors, aortic aneurysms, atherosclerosis, and cardiomyopathy …

Hepatocellular carcinoma (HCC), is the sixth most frequent form of cancer and leads to the
fourth highest number of deaths each year. HCC results from a combination of …

Primary liver cancer is characterized by molecular heterogeneity and limited treatment
options. We present the RPK mouse model as a novel platform to study key molecular …