[HTML][HTML] SARS-CoV-2: structure, biology, and structure-based therapeutics development
MY Wang, R Zhao, LJ Gao, XF Gao… - Frontiers in cellular …, 2020 - frontiersin.org
The pandemic of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
has been posing great threats to the world in many aspects. Effective therapeutic and …
has been posing great threats to the world in many aspects. Effective therapeutic and …
[HTML][HTML] Role of angiotensin-converting enzyme 2 (ACE2) in COVID-19
W Ni, X Yang, D Yang, J Bao, R Li, Y Xiao, C Hou… - Critical Care, 2020 - Springer
An outbreak of pneumonia caused by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) that started in Wuhan, China, at the end of 2019 has become a global …
(SARS-CoV-2) that started in Wuhan, China, at the end of 2019 has become a global …
[HTML][HTML] Human organoids: model systems for human biology and medicine
The historical reliance of biological research on the use of animal models has sometimes
made it challenging to address questions that are specific to the understanding of human …
made it challenging to address questions that are specific to the understanding of human …
[HTML][HTML] Viral presence and immunopathology in patients with lethal COVID-19: a prospective autopsy cohort study
B Schurink, E Roos, T Radonic, E Barbe… - The Lancet …, 2020 - thelancet.com
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) targets
multiple organs and causes severe coagulopathy. Histopathological organ changes might …
multiple organs and causes severe coagulopathy. Histopathological organ changes might …
Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19
Although most severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–infected
individuals experience mild coronavirus disease 2019 (COVID-19), some patients suffer …
individuals experience mild coronavirus disease 2019 (COVID-19), some patients suffer …
[HTML][HTML] Viable SARS-CoV-2 in the air of a hospital room with COVID-19 patients
Objectives Because the detection of SARS-CoV-2 RNA in aerosols but failure to isolate
viable (infectious) virus are commonly reported, there is substantial controversy whether …
viable (infectious) virus are commonly reported, there is substantial controversy whether …
[PDF][PDF] SARS-CoV-2 infects the brain choroid plexus and disrupts the blood-CSF barrier in human brain organoids
Summary Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) virus, leads to respiratory symptoms that can be …
syndrome coronavirus 2 (SARS-CoV-2) virus, leads to respiratory symptoms that can be …
TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes
R Zang, MFG Castro, BT McCune, Q Zeng… - Science …, 2020 - science.org
Gastrointestinal symptoms and fecal shedding of SARS-CoV-2 RNA are frequently observed
in COVID-19. However, it is unclear whether SARS-CoV-2 replicates in the human intestine …
in COVID-19. However, it is unclear whether SARS-CoV-2 replicates in the human intestine …
[HTML][HTML] Extrapulmonary manifestations of COVID-19
A Gupta, MV Madhavan, K Sehgal, N Nair… - Nature medicine, 2020 - nature.com
Although COVID-19 is most well known for causing substantial respiratory pathology, it can
also result in several extrapulmonary manifestations. These conditions include thrombotic …
also result in several extrapulmonary manifestations. These conditions include thrombotic …
[HTML][HTML] Interplay between SARS-CoV-2 and the type I interferon response
M Sa Ribero, N Jouvenet, M Dreux, S Nisole - PLoS pathogens, 2020 - journals.plos.org
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for the
current COVID-19 pandemic. An unbalanced immune response, characterized by a weak …
current COVID-19 pandemic. An unbalanced immune response, characterized by a weak …