Keratin intermediate filament proteins are major cytoskeletal components of the mammalian
simple layered columnar epithelium in the gastrointestinal tract. Human colon crypt epithelial …

Skeletal muscle and the nervous system depend on efficient protein quality control, and they
express chaperones and cochaperones at high levels to maintain protein homeostasis …

Elucidation of the mitochondrial regulatory mechanisms for the understanding of muscle
bioenergetics and the role of mitochondria is a fundamental problem in cellular physiology …

Mitochondria change distribution across cells following a variety of pathophysiological
stimuli. The mechanisms presiding over this redistribution are yet undefined. In a murine …

Background: The pleomorphic clinical presentation makes the diagnosis of desminopathy
difficult. We aimed to describe the prevalence, phenotypic expression, and mitochondrial …

Desmin intermediate filaments (IFs) play an important role in maintaining the structural and
functional integrity of muscle cells. They connect contractile myofibrils to plasma membrane …

Desmin, being a major intermediate filament of muscle cells, contributes to stabilization and
positioning of mitochondria. Desmin mutations have been reported in conjunction with …

Desmin is the major protein component of the intermediate filaments (IFs) cytoskeleton in
muscle cells, including cardiac. The accumulation of cleaved and misfolded desmin is a …

Patients with chronic obstructive pulmonary disease (COPD) usually develop skeletal
muscle dysfunction, which represents a major comorbidity in these patients and is strongly …

Homeostasis in vertebrate systems is contingent on normal cardiac function. This, in turn,
depends on intricate protein-based cellular machinery, both for contractile function, as well …