Protein-based therapeutics have unique therapeutic potential due to their specificity,
potency, and low toxicity. The vast majority of intracellular applications of proteins require …

One of the features distinguishing SARS-CoV-2 from its more pathogenic counterpart SARS-
CoV is the presence of premature stop codons in its ORF3b gene. Here, we show that SARS …

In biomedical research, there is an ongoing demand for new technologies to elucidate
disease mechanisms and develop novel therapeutics. This requires comprehensive …

A nuclear localisation sequence (NLS) peptide, PAAKRVKLD, derived from the human c-
Myc regulator gene, has been functionalised with a long wavelength (λex= 550 nm; λem …

Cas13a, an effector of type VI CRISPR-Cas systems, is an RNA guided RNase with
multiplexing and therapeutic potential. This study employs the Leptotrichia shahii (Lsh) …

Precise genetic engineering in specific cell types within an intact organism is intriguing yet
challenging, especially in a spatiotemporal manner without the interference caused by …

ABSTRACT Human bocavirus 1 (HBoV1), which belongs to the genus Bocaparvovirus of the
Parvoviridae family, causes acute respiratory tract infections in young children. In vitro …

While BDNF is receiving considerable attention for its role in synaptic plasticity and in
nervous system dysfunction, identifying brain circuits involving BDNF-expressing neurons …

Effector proteins are recruited to chromatin via transient interactions between their reader
domains and histone post-translational modification (PTM) patterns. These interactions form …

Macrophages, phagocytic cells of the innate immune system, are the body's first line of
defense against pathogens and are responsible for tissue maintenance. Macrophages are …