Ferroptosis is a form of regulated cell death that is characterized by iron-dependent
oxidative damage and subsequent plasma membrane ruptures and the release of damage …

Iron is biologically essential, but also potentially toxic; as such it is tightly controlled at cell
and systemic levels to prevent both deficiency and overload. Iron regulatory proteins post …

Macroautophagy (hereafter referred to as autophagy) is an evolutionarily conserved cellular
process capable of degrading various biological molecules (eg, protein, glycogen, lipids …

Cellular iron, at the physiological level, is essential to maintain several metabolic pathways,
while an excess of free iron may cause oxidative damage and/or provoke cell death …

Ferroptosis is a non-apoptotic mode of regulated cell death that is iron and lipid peroxidation
dependent. As new mechanistic insight into ferroptotic effectors and how they are regulated …

Redox balance is essential for normal brain, hence dis-coordinated oxidative reactions
leading to neuronal death, including programs of regulated death, are commonly viewed as …

New and provocative insights into the relationships between iron and cancer have been
uncovered in recent years. These include delineation of connections that link cellular iron to …

Autophagy is a conserved process to maintains homeostasis via the degradation of toxic cell
contents, which can either promote cell survival or accelerate cellular demise. Ferroptosis is …

Mitochondrial quality is controlled by the selective removal of damaged mitochondria
through mitophagy. Mitophagy impairment is associated with aging and many pathological …

Ferroptosis, a recently discovered form of iron-dependent cell death, requires an increased
level of lipid-reactive oxygen species (ROS). Ferritinophagy, a ferritin degradation pathway …