Tuberculosis continues to be a major threat to global health. Cavitation is a dangerous
consequence of pulmonary tuberculosis associated with poor outcomes, treatment relapse …

Caseum, the central necrotic material of tuberculous lesions, is a reservoir of drug-
recalcitrant persisting mycobacteria. Caseum is found in closed nodules and in open …

Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), has co‐evolved with
the human immune system and utilizes multiple strategies to persist within infected cells, to …

Given that infection with Mycobacterium tuberculosis (Mtb) is the leading cause of death
amongst individuals living with HIV, understanding the complex mechanisms by which Mtb …

Mitochondria, are undoubtedly critical organelle of a eukaryotic cell, which provide energy
and offer a platform for most of the cellular signaling pathways that decide cell fate. The role …

Mycobacterium tuberculosis (Mtb) infects macrophages and macrophage-derived foam
cells, a hallmark of granulomata in tuberculous lesions. We analyzed the effects of lipid …

The ability of Mycobacterium tuberculosis (Mtb) to persist inside host cells relies on
metabolic adaptation, like the accumulation of lipid bodies (LBs) in the so-called foamy …

Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinase (TIMPs) are
potential regulators of tuberculosis (TB) pathology. Whether they are candidates for non …

Lipids are a broad group of molecules required for cell maintenance and homeostasis.
Various intracellular pathogens have developed mechanisms of modulating and …

Mycobacterium tuberculosis (M. tb) is likely the most successful human pathogen, capable of
evading protective host immune responses and driving metabolic changes to support its …