Diffuse optical imaging (DOI) is a label-free, safe, inexpensive, and quantitative imaging
modality that provides metabolic and molecular contrast in tissue using visible or near …

This work reviews physical concepts, technologies and applications of time-domain diffuse
optics based on time-gated single-photon detection. This particular photon detection …

We present the design and characterization of a large-area, fast-gated, all-digital single-
photon detector with programmable active area, internal gate generator, and time-todigital …

Time-domain diffuse optics is a powerful non-invasive, non-ionizing and label-free
technique based on the use of picosecond pulsed laser light to probe highly scattering …

The human abdominal region is very heterogeneous and stratified with subcutaneous
adipose tissue (SAT) being one of the primary layers. Monitoring this tissue is crucial for …

In many clinical applications it is relevant to observe dynamic changes in oxygenation.
Therefore the ability of dynamic imaging with time domain (TD) near-infrared optical …

The ability to image through turbid media, such as organic tissues, is a highly attractive
prospect for biological and medical imaging. This is challenging, however, due to the highly …

Two main bottlenecks prevent time-domain diffuse optics instruments to reach their
maximum performances, namely the limited light harvesting capability of the detection chain …

Near infrared optical tomography (NIROT) is an emerging modality that enables imaging the
oxygenation of tissue, which is a biomarker of tremendous clinical relevance. Measuring in …

Near-infrared spectroscopy has proven to be a valuable method to monitor tissue
oxygenation and haemodynamics non-invasively and in real-time. Quantification of such …