Small molecule based five-membered heterocycles: A view of liquid crystalline properties beyond the biological applications

SY Kotian, CD Mohan, AA Merlo, S Rangappa… - Journal of Molecular …, 2020 - Elsevier
Liquid crystal (LC) is an intermediate phase of matter with the physical attributes of liquid,
and a high-level of orientational order of solids. This property of LCs has been widely …

Computer-aided drug design applied to secondary metabolites as anticancer agents

RSA de Araújo, EF da Silva-Junior… - Current Topics in …, 2020 - ingentaconnect.com
Computer-Aided Drug Design (CADD) techniques have garnered a great deal of attention in
academia and industry because of their great versatility, low costs, possibilities of cost …

Effects of taraxasterol against ethanol and high-fat diet-induced liver injury by regulating TLR4/MyD88/NF-κB and Nrf2/HO-1 signaling pathways

Z Li, Y Lian, R Wei, L Jin, H Cao, T Zhao, X Ma… - Life sciences, 2020 - Elsevier
Studies have reported that taraxasterol (TAR) is effective in the treatment of immune liver
injury and alcoholic liver injury. The mechanism of action is mainly related to the inhibition of …

Anti-neoplastic effect of ginkgolide C through modulating c-met phosphorylation in hepatocellular carcinoma cells

MH Yang, SH Baek, JY Um, KS Ahn - International journal of molecular …, 2020 - mdpi.com
Ginkgolide C (GGC) derived from Ginkgo biloba, has been reported to exhibit various
biological functions. However, the anti-neoplastic effect of GGC and its mechanisms in liver …

Allelochemical Activity of Eugenol-Derived Coumarins on Lactuca sativa L.

KP Govêa, RST Pereira, MDO de Assis, PI Alves… - Plants, 2020 - mdpi.com
Coumarins are widely distributed substances in plant species that promote phytotoxic
effects, allowing them to be exploited as herbicides less harmful to the environment, since …

[HTML][HTML] Identification of a novel 1, 2 oxazine that can induce apoptosis by targeting NF-κB in hepatocellular carcinoma cells

C Somu, CD Mohan, S Ambekar, S Rangappa… - Biotechnology …, 2020 - Elsevier
Constitutive activation of NF-κB is associated with proinflammatory diseases and
suppression of the NF-κB signaling pathway has been considered as an effective …

[HTML][HTML] A QSAR study on the 4-substituted coumarins as potent tubulin polymerization inhibitors

L Dinparast, S Dastmalchi - Advanced Pharmaceutical Bulletin, 2020 - ncbi.nlm.nih.gov
Purpose: Despite the discovery and synthesis of several anticancer drugs, cancer is still a
major life threatening incident for human beings after cardiovascular diseases. Toxicity …

[PDF][PDF] ИЗУЧЕНИЕ МЕХАНИЗМОВ ПРОТИВООПУХОЛЕВОГО ДЕЙСТВИЯ ПРОИЗВОДНОГО 4-АМИНОХРОМЕНА (in vivo и in vitro исследование)

ЕВ Блинова - 2020 - sechenov.ru
Злокачественные новообразования, определяемые как совокупность заболеваний,
характеризующихся неконтролируемым ростом и распространением атипичных …

Tris DBA Abrogates Tumor Progression in Hepatocellular Carcinoma and Multiple Myeloma Preclinical Models by Affecting Multiple Oncogenic Proteins

L Arora, CD Mohan, C Kim, S Rangappa… - 2020 - researchsquare.com
Background: STAT3 is an oncogenic transcription factor that controls the expression of
genes associated with proliferation, apoptotic resistance, malignant transformation, and …

The Role of Cytochrome P450 1A2 in Tumor Suppression and Sorafenib-Resistance in Hepatocellular Carcinoma

J Yu - 2020 - search.proquest.com
Background Hepatocellular carcinoma (HCC) is the commonest primary liver cancer and
ranked as the fourth cause of cancer mortality worldwide. The cytochrome P450 1A2 …