Risk of major gastrointestinal bleeding with new vs conventional oral anticoagulants: a systematic review and meta-analysis

ZC Gu, AH Wei, C Zhang, XH Wang, L Zhang… - Clinical …, 2020 - Elsevier
Background & Aims There is controversy over whether use of non-vitamin K antagonist oral
anticoagulants (NOACs) associates with increased risk of major gastrointestinal bleeding …

[HTML][HTML] Diagnosis and management of non-variceal gastrointestinal hemorrhage: a review of current guidelines and future perspectives

S Mujtaba, S Chawla, JF Massaad - Journal of clinical medicine, 2020 - mdpi.com
Non-variceal gastrointestinal bleeding (GIB) is a significant cause of mortality and morbidity
worldwide which is encountered in the ambulatory and hospital settings. Hemorrhage form …

Validation of a machine learning model that outperforms clinical risk scoring systems for upper gastrointestinal bleeding

DL Shung, B Au, RA Taylor, JK Tay, SB Laursen… - Gastroenterology, 2020 - Elsevier
Background & Aims Scoring systems are suboptimal for determining risk in patients with
upper gastrointestinal bleeding (UGIB); these might be improved by a machine learning …

A proof‐of‐concept, Phase 2 clinical trial of the gastrointestinal safety of a hydrogen sulfide‐releasing anti‐inflammatory drug

JL Wallace, P Nagy, TD Feener, T Allain… - British journal of …, 2020 - Wiley Online Library
Background and Purpose ATB‐346 is a hydrogen sulfide (H2S)‐releasing anti‐inflammatory
and analgesic drug. Animal studies demonstrated negligible gastrointestinal (GI) damage …

[HTML][HTML] Efficacy and safety of early vs elective colonoscopy for acute lower gastrointestinal bleeding

R Niikura, N Nagata, A Yamada, T Honda, K Hasatani… - Gastroenterology, 2020 - Elsevier
Background & Aims We performed a large, multicenter, randomized controlled trial to
determine the efficacy and safety of early colonoscopy on outcomes of patients with acute …

External validation of the Oakland score to assess safe hospital discharge among adult patients with acute lower gastrointestinal bleeding in the US

K Oakland, S Kothiwale, T Forehand… - JAMA network …, 2020 - jamanetwork.com
Importance Lower gastrointestinal bleeding (LGIB), which manifests as blood in the colon or
anorectum, is a common reason for hospitalization. In most patients, LGIB stops …

Thirty-year incidence and mortality trends in upper and lower gastrointestinal bleeding in Finland

P Vora, A Pietila, M Peltonen, G Brobert… - JAMA network …, 2020 - jamanetwork.com
Importance Epidemiological data on lower gastrointestinal bleeding (GIB) in the general
population are sparse. Objective To describe the incidence, recurrence, mortality, and case …

[HTML][HTML] Potential strategies in the prevention of nonsteroidal anti-inflammatory drugs-associated adverse effects in the lower gastrointestinal tract

CG Guo, WK Leung - Gut and liver, 2020 - ncbi.nlm.nih.gov
With the increasing use of nonsteroidal anti-inflammatory drugs (NSAIDs), the incidence of
lower gastrointestinal (GI) complications is expected to increase. However, unlike upper GI …

Interventional algorithm in gastrointestinal bleeding—an expert consensus multimodal approach based on a multidisciplinary team

A Rodrigues, A Carrilho, N Almeida… - Clinical and Applied …, 2020 - journals.sagepub.com
The approach to the patient with gastrointestinal bleeding (GIB) can be very complex. A
multidisciplinary panel of physicians with expertise in Gastroenterology, Anesthesiology …

[HTML][HTML] Glycomacropeptide ameliorates indomethacin-induced enteropathy in rats by modifying intestinal inflammation and oxidative stress

D Cervantes-García, AI Bahena-Delgado, M Jiménez… - Molecules, 2020 - mdpi.com
Nonsteroidal anti-inflammatory drug (NSAID)-induced enteropathy is considered a serious
and increasing clinical problem without available treatment. Glycomacropeptide (GMP) is a …