Cancer-associated fibroblasts (CAFs) are a key component of the tumour microenvironment
with diverse functions, including matrix deposition and remodelling, extensive reciprocal …

Multiple nanotherapeutics have been approved for patients with cancer, but their effects on
survival have been modest and, in some examples, less than those of other approved …

Metastasis is a dynamic succession of events involving the dissemination of tumour cells to
distant sites within the body, ultimately reducing the survival of patients with cancer. To …

Tumors are influenced by the mechanical properties of their microenvironment. Using
patient samples and atomic force microscopy, we found that tissue stiffness is higher in liver …

Advances in immunotherapy have revolutionized the treatment of multiple cancers.
Unfortunately, tumors usually have impaired blood perfusion, which limits the delivery of …

Simple Summary The extracellular matrix (ECM) is the acellular part of a tissue, a meshwork
of extracellular material produced and secreted by cells into the surrounding medium. The …

Pancreatic ductal adenocarcinoma (PDAC) is a malignancy with one of the worst prognoses
worldwide and has an overall 5-year survival rate of only 9%. Although chemotherapy is the …

Immunotherapy is poised to become an increasingly utilized therapy in the treatment of
cancer. However, several abnormalities in the tumor microenvironment (TME) that can …

High-salt diets are associated with an elevated risk of autoimmune diseases, and immune
dysregulation plays a key role in cancer development. However, the correlation between …

To penetrate solid tumors, low molecular weight (Mw< 10 KDa) compounds have an edge
over antibodies: their higher penetration because of their small size. Because of the dense …