Melanoma is one of the most immunologic malignancies based on its higher prevalence in
immune‐compromised patients, the evidence of brisk lymphocytic infiltrates in both primary …

Nearly 15% of melanomas occur in patients with a family history and a subset of these
patients have a germline mutation in a melanoma predisposing gene. CDKN2A mutations …

The live-attenuated oral poliovirus vaccine (OPV or Sabin vaccine) replicates in gut-
associated tissues, eliciting mucosa and systemic immunity. OPV protects from disease and …

Purpose: Over 60% of patients with melanoma respond to immune checkpoint inhibitor (ICI)
therapy, but many subsequently progress on these therapies. Second-line targeted therapy …

Dermatologists stand at the gateway of individualization of classification, treatment, and
outcomes of acral melanoma patients. The acral melanoma genetic landscape differs in vital …

Background Molecularly targeted therapy has revolutionized the treatment of advanced
melanoma. However, despite its high efficiency, a majority of patients experience relapse …

Coronin 1C is overexpressed in multiple tumors, leading to the widely held view that this
gene drives tumor progression, but this hypothesis has not been rigorously tested in …

Data on the KIT mutation rate in melanoma in the central European region is missing.
Accordingly, in a cohort of 79 BRAF/NRAS double wild type cutaneous melanoma and 17 …

Background Melanoma is one of the major types of skin cancer. The metastatic melanoma is
among the most lethal forms of malignant skin tumors. We hereby aimed to characterize a …

Mutations in MAPK signalling genes are driver events in melanoma, and have therapeutic
relevance in the metastatic and adjuvant setting. This study evaluated the intra-patient …