Targeting CDK2 in cancer: challenges and opportunities for therapy
Highlights•CDK2 has key roles in cell cycle, DNA replication and DNA damage.•Multiple
biomarkers can indicate increased CDK2 activity.•Some cancers have particular …
biomarkers can indicate increased CDK2 activity.•Some cancers have particular …
Circular RNA-ZNF532 regulates diabetes-induced retinal pericyte degeneration and vascular dysfunction
Q Jiang, C Liu, CP Li, SS Xu, MD Yao… - The Journal of …, 2020 - Am Soc Clin Investig
Diabetic retinopathy (DR) is the leading cause of blindness in working-age adults. Vascular
pericyte degeneration is the predominant clinical manifestation of DR, yet the mechanism …
pericyte degeneration is the predominant clinical manifestation of DR, yet the mechanism …
Xanthohumol, a prenylated flavonoid from hops, induces DNA damages in colorectal cancer cells and sensitizes SW480 cells to the SN38 chemotherapeutic agent
A Scagliarini, A Mathey, V Aires, D Delmas - Cells, 2020 - mdpi.com
In spite of chemotherapy and systematic screening for people at risk, the mortality rate of
colorectal cancer (CRC) remains consistently high, with 600,000 deaths per year. This low …
colorectal cancer (CRC) remains consistently high, with 600,000 deaths per year. This low …
A precision medicine drug discovery pipeline identifies combined CDK2 and 9 inhibition as a novel therapeutic strategy in colorectal cancer
JA Somarelli, RS Roghani, AS Moghaddam… - Molecular cancer …, 2020 - AACR
Colorectal cancer is the third most common cancer in the United States and responsible for
over 50,000 deaths each year. Therapeutic options for advanced colorectal cancer are …
over 50,000 deaths each year. Therapeutic options for advanced colorectal cancer are …
Regulation of airway smooth muscle proliferation by β2-adrenoceptor agonists
AG Stewart, PR Tomlinson… - Airway wall remodelling in …, 2020 - taylorfrancis.com
This chapter reviews the regulation of β2-adrenoceptors in asthma and the effects of β2-
adrenoceptor agonists on airway smooth muscle proliferation. It examines the interaction …
adrenoceptor agonists on airway smooth muscle proliferation. It examines the interaction …
[PDF][PDF] Frequency of CDK2, CCNE1 Copy Number Variation in Acral Melanoma and Implications for CDK Inhibitor in Targeted Therapy
X Wu, J Yan, J Yu, J Yu, Z Cheng, T Yin, Q Guo, Y Xie… - 2020 - pdfs.semanticscholar.org
Background: Acral melanoma have a high frequency of cell cycle-related gene copy number
variation. However, the status and clinical signi cance of CNVs of CDK 2 and CCNE1 have …
variation. However, the status and clinical signi cance of CNVs of CDK 2 and CCNE1 have …
In vivo models of smooth muscle growth
JG Martin, TR Bai - Airway wall remodelling in asthma, 2020 - taylorfrancis.com
Airway smooth muscle is presumed to be the major effector of the airway narrowing that
occurs during bronchial provocation testing. The sensitivity of induced bronchoconstriction to …
occurs during bronchial provocation testing. The sensitivity of induced bronchoconstriction to …