Toward a fully resolved fungal tree of life

TY James, JE Stajich, CT Hittinger… - Annual Review of …, 2020 - annualreviews.org
In this review, we discuss the current status and future challenges for fully elucidating the
fungal tree of life. In the last 15 years, advances in genomic technologies have …

Cryptococcosis

S Zavala, JW Baddley - Seminars in respiratory and critical care …, 2020 - thieme-connect.com
Cryptococcosis has become an important infection in both immunocompromised and
immunocompetent hosts. Although Cryptococcus is mainly recognized by its ability to cause …

Fungal species concepts in the genomics era

J Xu - Genome, 2020 - cdnsciencepub.com
The 140 000 or so fungal species reported so far are heterogeneously defined based on
varying criteria such as morphological, physiological, mating, and (or) molecular features …

[HTML][HTML] 5-fluorocytosine resistance is associated with hypermutation and alterations in capsule biosynthesis in Cryptococcus

RB Billmyre, S Applen Clancey, LX Li… - Nature …, 2020 - nature.com
Patients infected with the fungal pathogen Cryptococcus are most effectively treated with a
combination of 5-fluorocytosine (5FC) and amphotericin B. 5FC acts as a prodrug, which is …

The interplay of phenotype and genotype in Cryptococcus neoformans disease

S Altamirano, KM Jackson, K Nielsen - Bioscience Reports, 2020 - portlandpress.com
Cryptococcus neoformans is an opportunistic fungal pathogen that causes life-threatening
meningitis primarily in immunocompromised individuals. In order to survive and proliferate …

[HTML][HTML] Hybridization facilitates adaptive evolution in two major fungal pathogens

H Samarasinghe, M You, TS Jenkinson, J Xu… - Genes, 2020 - mdpi.com
Hybridization is increasingly recognized as an important force impacting adaptation and
evolution in many lineages of fungi. During hybridization, divergent genomes and alleles are …

[HTML][HTML] Microbiological, epidemiological, and clinical characteristics of patients with cryptococcal meningitis at a tertiary hospital in China: a 6-year retrospective …

Y Li, M Zou, J Yin, Z Liu, B Lu - Frontiers in Microbiology, 2020 - frontiersin.org
Cryptococcal meningitis, mainly caused by Cryptococcus neoformans/gattii species
complexes, is a lethal infection in both immunosuppressive and immunocompetent …

Otomycosis Due to the Rare Fungi Talaromyces purpurogenus, Naganishia albida and Filobasidium magnum

S Aboutalebian, S Mahmoudi, A Okhovat… - Mycopathologia, 2020 - Springer
Otomycosis is a common finding in otorhinolaryngology clinics and is usually caused by
species of Candida and Aspergillus, particularly black aspergilli. Meanwhile, other fungi can …

[HTML][HTML] Mitochondrial Genome Polymorphisms in the Human Pathogenic Fungus Cryptococcus neoformans

Y Wang, J Xu - Frontiers in Microbiology, 2020 - frontiersin.org
The Cryptococcus complex consists of at least seven evolutionary divergent lineages and
causes∼ 200,000 fatal human infections each year worldwide. The dominant lineage is …

Titan cell formation is unique to Cryptococcus species complex

M Dyląg, RJ Colon-Reyes, L Kozubowski - Virulence, 2020 - Taylor & Francis
Members of the Cryptococcus species complex stand out by unique virulence factors that
allowed evolutionary transition to pathogenesis. Among the factors contributing to …