The complex pathophysiological mechanisms behind destructive chronic conditions,
including cancer, neurodegenerative diseases, diabetes mellitus, cardiovascular diseases …

The activation of the PI3K/AKT/mTOR pathway is a main driver of cell growth, proliferation,
survival, and chemoresistance of cancer cells, and, for this reason, represents an attractive …

Radiation‐induced enteritis is one of the greatest challenges in radiotherapy. The current
study was designed to evaluate the ameliorative effect of resveratrol, which exhibits anti …

Modulating the activity of the Src Homology 2 (SH2)—containing Inositol 5′-Phosphatase
(SHIP) enzyme family with small molecule inhibitors provides a useful and unconventional …

Autophagy, an evolutionarily conserved mechanism that promotes cell survival by recycling
nutrients and degrading long-lived proteins and dysfunctional organelles, is an important …

Objective: This study was conducted to determine whether regulatory T cells (CD4+ CD25+
T, Tregs) show abnormal mitophagy as well as the function of Tregs in patients with …

PKC-mediated inflammation is important in ovarian physiology. The roles of Akt and protein
phosphatase 2A (PP2A) in PKC-mediated inflammation in ovarian granulosa cells (GCs) …

A macrocyclization approach has been explored on a series of benzoxazine
phosphoinositide 3-kinase δ inhibitors, resulting in compounds with improved potency …

Provided are novel crystals of [2-(1-methyl-1H-pyrazol-4-yl)-6-(morpholin-4-yl)-9H-purin-8-
yl][4-(morpholin-4-yl) piperidin-1-yl] methanone and a pharmaceutically acceptable salt …