Forkhead box O transcription factors (FOXOs) regulate several signaling pathways and play
crucial roles in health and disease. FOXOs are key regulators of the expression of genes …

Autophagy is a highly conserved intracellular degradation process that plays a crucial role in
cell survival and stress reactions as well as in cancer development and metastasis …

Dysregulation of polyamine metabolism has been linked to the development of colorectal
cancer (CRC), but the underlying mechanism is incompletely characterized. Here, we report …

Osimertinib, a third‐generation irreversible epidermal growth factor receptor tyrosine kinase
inhibitor (EGFR‐TKI), provides marked clinical benefit for patients with EGFR‐activating …

As the unique source of diverse immunoglobulin repertoires, B lymphocytes are an
indispensable part of humoral immunity. B cell progenitors progress through sequential and …

Pharmaceutical inhibitors of the endoplasmic reticulum (ER)-stress modulator PERK
(eIF2AK3) have demonstrated anticancer activities in combination therapies, but their …

Ras recruits and activates effectors that transmit receptor-initiated signals. Monomeric Ras
can bind Raf; however, Raf's activation requires dimerization, which can be facilitated by …

Abstract V (D) J recombination is a spatially and temporally restricted process, and depends
heavily on epigenetic regulation to provide this control. The failure of V (D) J recombination …

Background: Accumulating evidence has implicated a pivotal role for FOXO3, FOXM1 and
SIRT6 in cancer progression and metastasis. The majority of researches have focused on …

The human leukaemia develops with abnormal increase of blast cells in the bone marrow.
Leukaemia is caused by genetic aberrations which activates proto-oncogenes and …