Risk of colorectal cancer in inflammatory bowel diseases

MS Nadeem, V Kumar, FA Al-Abbasi, MA Kamal… - Seminars in cancer …, 2020 - Elsevier
Inflammatory bowel diseases (IBDs) are chronic problems of gastrointestinal tract (GIT) with
poorly understood aetiology. Patients with any of the two common entities, Crohn's disease …

Revisiting inflammatory bowel disease: pathology, treatments, challenges and emerging therapeutics including drug leads from natural products

K Yeshi, R Ruscher, L Hunter, NL Daly… - Journal of clinical …, 2020 - mdpi.com
Inflammatory bowel disease (IBD) is a chronic and life-long disease characterized by
gastrointestinal tract inflammation. It is caused by the interplay of the host's genetic …

Neutrophil extracellular traps induce intestinal damage and thrombotic tendency in inflammatory bowel disease

T Li, C Wang, Y Liu, B Li, W Zhang… - Journal of Crohn's …, 2020 - academic.oup.com
Abstract Background and Aims Despite the presence of neutrophil extracellular traps [NETs]
in inflamed colon having been confirmed, the role of NETs, especially the circulating NETs …

Gut microbiota and metabolic specificity in ulcerative colitis and Crohn's disease

J Sankarasubramanian, R Ahmad, N Avuthu… - Frontiers in …, 2020 - frontiersin.org
Background: Inflammatory bowel disease (IBD) represents multifactorial chronic
inflammatory conditions in the gastrointestinal tract and includes Crohn's disease (CD) and …

Sphingosine kinase and sphingosine-1-phosphate receptor signaling pathway in inflammatory gastrointestinal disease and cancers: A novel therapeutic target

OA Sukocheva, H Furuya, ML Ng, M Friedemann… - Pharmacology & …, 2020 - Elsevier
Inflammatory gastrointestinal (GI) diseases and malignancies are associated with growing
morbidity and cancer-related mortality worldwide. GI tumor and inflammatory cells contain …

Macrophage-based nanotherapeutic strategies in ulcerative colitis

J Zhang, Y Zhao, T Hou, H Zeng, D Kalambhe… - Journal of Controlled …, 2020 - Elsevier
Macrophages, an important component of the innate immune response, are a key regulator
of intestinal microenvironment homeostasis. These cells essentially contribute to chronic …

Ficus carica polysaccharide attenuates DSS-induced ulcerative colitis in C57BL/6 mice

Q Zou, X Zhang, X Liu, Y Li, Q Tan, Q Dan, T Yuan… - Food & function, 2020 - pubs.rsc.org
The Ficus carica polysaccharide (FCPS) components of the common fig fruit have been
demonstrated to exhibit antioxidant and immunity-enhancing activities. However, it is …

Sex differences in the gut-brain axis: implications for mental health

C Holingue, AC Budavari, KM Rodriguez… - Current psychiatry …, 2020 - Springer
Abstract Purpose of Review The purpose of this article is to highlight how sex differences in
the gut-brain axis may contribute to the discrepancies in incidence of neurodevelopmental …

Treatment algorithm for mild and moderate-to-severe ulcerative colitis: an update

E Burri, MH Maillard, AM Schoepfer, F Seibold… - Digestion, 2020 - karger.com
Background: Patient care in ulcerative colitis (UC) remains challenging despite an array of
established treatment options and emerging new therapies. The management of UC therapy …

Melatonin controls microbiota in colitis by goblet cell differentiation and antimicrobial peptide production through Toll-like receptor 4 signalling

SW Kim, S Kim, M Son, JH Cheon, YS Park - Scientific reports, 2020 - nature.com
Microbial dysbiosis has long been postulated to be associated with the pathogenesis of
inflammatory bowel disease (IBD). Although evidence supporting the anti-colitic effects of …