Fluid biomarkers for synaptic dysfunction and loss
E Camporesi, J Nilsson, A Brinkmalm… - Biomarker …, 2020 - journals.sagepub.com
Synapses are the site for brain communication where information is transmitted between
neurons and stored for memory formation. Synaptic degeneration is a global and early …
neurons and stored for memory formation. Synaptic degeneration is a global and early …
The two faces of synaptic failure in AppNL-GF knock-in mice
A Latif-Hernandez, V Sabanov, T Ahmed… - Alzheimer's research & …, 2020 - Springer
Background Intensive basic and preclinical research into Alzheimer's disease (AD) has
yielded important new findings, but they could not yet been translated into effective …
yielded important new findings, but they could not yet been translated into effective …
Acute pannexin 1 blockade mitigates early synaptic plasticity defects in a mouse model of Alzheimer's disease
C Flores-Muñoz, B Gómez, E Mery, P Mujica… - Frontiers in Cellular …, 2020 - frontiersin.org
Synaptic loss induced by soluble oligomeric forms of the amyloid β peptide (sAβos) is one of
the earliest events in Alzheimer's disease (AD) and is thought to be the major cause of the …
the earliest events in Alzheimer's disease (AD) and is thought to be the major cause of the …
A pilot study comparing effects of bifrontal versus bitemporal transcranial direct current stimulation in mild cognitive impairment and mild Alzheimer disease
Objective While transcranial direct current stimulation (tDCS) can enhance aspects of
memory in patients with mild cognitive impairment (MCI) and Alzheimer disease (AD), there …
memory in patients with mild cognitive impairment (MCI) and Alzheimer disease (AD), there …
Increased levels of Stress-inducible phosphoprotein-1 accelerates amyloid-β deposition in a mouse model of Alzheimer's disease
RE Lackie, J Marques-Lopes, VG Ostapchenko… - Acta neuropathologica …, 2020 - Springer
Molecular chaperones and co-chaperones, which are part of the protein quality control
machinery, have been shown to regulate distinct aspects of Alzheimer's Disease (AD) …
machinery, have been shown to regulate distinct aspects of Alzheimer's Disease (AD) …
Novel huperzine A based NMDA antagonists: insights from molecular docking, ADME/T and molecular dynamics simulation studies
DK Sigalapalli, R Rangaswamy, ND Tangellamudi - RSC advances, 2020 - pubs.rsc.org
Huperzine A (HupA) is an alkaloidal natural product and drug isolated from Chinese herb
Huperzia serrata, which is a potent selective anticholinesterase inhibitor. HupA has …
Huperzia serrata, which is a potent selective anticholinesterase inhibitor. HupA has …
Anti-Aβ globulomer 4D10 antibodies
S Barghorn, H Hillen, B Labkovsky… - US Patent …, 2020 - Google Patents
2018-05-02 Assigned to AbbVie Deutschland GmbH & Co. KG reassignment AbbVie
Deutschland GmbH & Co. KG ASSIGNMENT OF ASSIGNORS INTEREST (SEE …
Deutschland GmbH & Co. KG ASSIGNMENT OF ASSIGNORS INTEREST (SEE …
[HTML][HTML] Differential Effect of Amyloid Beta1–40 on Short-term and Long-term Plasticity in Dentate Gyrus of a Rat Model of Alzheimer Disease
J Fahanik-Babaei, T Baluchnejadmojarad… - Basic and Clinical …, 2020 - ncbi.nlm.nih.gov
Methods: The experimental groups in this research included the control with no treatment,
sham-operated receiving the vehicle (normal saline), and Aβ-lesioned groups. For modeling …
sham-operated receiving the vehicle (normal saline), and Aβ-lesioned groups. For modeling …
Antibodies to amyloid beta
M Groves, S GUSTAVSSON, K HÖGLUND, D LOWNE… - 2020 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
49765450&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
49765450&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
Antibodies to amyloid beta
M Groves, S Gustavsson, K Höglund, C Lloyd… - US Patent …, 2020 - Google Patents
Antibody for human amyloid beta. Antibody selectively binds human amyloid beta 42
peptide over human amyloid beta 40 peptide. Antibodies specific for amyloid beta 42 as …
peptide over human amyloid beta 40 peptide. Antibodies specific for amyloid beta 42 as …