Fluid biomarkers for synaptic dysfunction and loss

E Camporesi, J Nilsson, A Brinkmalm… - Biomarker …, 2020 - journals.sagepub.com
Synapses are the site for brain communication where information is transmitted between
neurons and stored for memory formation. Synaptic degeneration is a global and early …

The two faces of synaptic failure in AppNL-GF knock-in mice

A Latif-Hernandez, V Sabanov, T Ahmed… - Alzheimer's research & …, 2020 - Springer
Background Intensive basic and preclinical research into Alzheimer's disease (AD) has
yielded important new findings, but they could not yet been translated into effective …

Acute pannexin 1 blockade mitigates early synaptic plasticity defects in a mouse model of Alzheimer's disease

C Flores-Muñoz, B Gómez, E Mery, P Mujica… - Frontiers in Cellular …, 2020 - frontiersin.org
Synaptic loss induced by soluble oligomeric forms of the amyloid β peptide (sAβos) is one of
the earliest events in Alzheimer's disease (AD) and is thought to be the major cause of the …

A pilot study comparing effects of bifrontal versus bitemporal transcranial direct current stimulation in mild cognitive impairment and mild Alzheimer disease

CS Liu, N Herrmann, D Gallagher, TK Rajji… - The journal of …, 2020 - journals.lww.com
Objective While transcranial direct current stimulation (tDCS) can enhance aspects of
memory in patients with mild cognitive impairment (MCI) and Alzheimer disease (AD), there …

Increased levels of Stress-inducible phosphoprotein-1 accelerates amyloid-β deposition in a mouse model of Alzheimer's disease

RE Lackie, J Marques-Lopes, VG Ostapchenko… - Acta neuropathologica …, 2020 - Springer
Molecular chaperones and co-chaperones, which are part of the protein quality control
machinery, have been shown to regulate distinct aspects of Alzheimer's Disease (AD) …

Novel huperzine A based NMDA antagonists: insights from molecular docking, ADME/T and molecular dynamics simulation studies

DK Sigalapalli, R Rangaswamy, ND Tangellamudi - RSC advances, 2020 - pubs.rsc.org
Huperzine A (HupA) is an alkaloidal natural product and drug isolated from Chinese herb
Huperzia serrata, which is a potent selective anticholinesterase inhibitor. HupA has …

Anti-Aβ globulomer 4D10 antibodies

S Barghorn, H Hillen, B Labkovsky… - US Patent …, 2020 - Google Patents
2018-05-02 Assigned to AbbVie Deutschland GmbH & Co. KG reassignment AbbVie
Deutschland GmbH & Co. KG ASSIGNMENT OF ASSIGNORS INTEREST (SEE …

[HTML][HTML] Differential Effect of Amyloid Beta1–40 on Short-term and Long-term Plasticity in Dentate Gyrus of a Rat Model of Alzheimer Disease

J Fahanik-Babaei, T Baluchnejadmojarad… - Basic and Clinical …, 2020 - ncbi.nlm.nih.gov
Methods: The experimental groups in this research included the control with no treatment,
sham-operated receiving the vehicle (normal saline), and Aβ-lesioned groups. For modeling …

Antibodies to amyloid beta

M Groves, S GUSTAVSSON, K HÖGLUND, D LOWNE… - 2020 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
49765450&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

Antibodies to amyloid beta

M Groves, S Gustavsson, K Höglund, C Lloyd… - US Patent …, 2020 - Google Patents
Antibody for human amyloid beta. Antibody selectively binds human amyloid beta 42
peptide over human amyloid beta 40 peptide. Antibodies specific for amyloid beta 42 as …