Current platinum-based drugs used in chemotherapy, like cisplatin and its derivatives, are
greatly limited due to side-effects and drug resistance. This has inspired the search for novel …

Phytochemicals and their metabolites are not considered essential nutrients in humans,
although an increasing number of well-conducted studies are linking their higher intake with …

In this paper, theoretical study on molecular geometry, vibrational, pharmaceutical and
electronic properties of the monomeric and dimeric structures of 1-benzothiophene-2 …

Stereoselective synthesis of trisubstituted alkenes is a long-standing challenge in organic
chemistry, due to the small energy differences between E and Z isomers of trisubstituted …

Although blocking estrogen-dependent signaling is a cornerstone of adjuvant treatment for
breast cancer, 25% of patients experience recurrent disease. Stroma events including innate …

Objective: To systematically review the human clinical trial published studies regarding a
dietary compound 3, 3ʹ-diindolylmethane (DIM) clinical efficacy towards the prevention and …

Abstract: Tamoxifen is one of the important tricyclicethylene moieties and recognized as an
important drug candidate because of extensive applications in the field of medicinal and …

Up to 80% of mammary carcinoma initially exhibit estrogen-dependent growth, which can be
treated by aromatase inhibitors or SERMs/SERDs. To increase the options after failure of the …

A new series of 3-(3, 4, 5-trimethoxyphenyl)-5-(2-(5-arylbenzo [b] thiophen-3-yl) oxa zol-5-yl)
isoxazole derivatives were designed and synthesized. All these derivatives were evaluated …

The identification of new factors that may function as cancer markers and become eventual
pharmacologic targets is a challenge that may influence the management of tumor …