The endocannabinoid system (ECS) acts as a negative feedback mechanism to suppress
synaptic transmission and plays a major role in a diverse range of brain functions including …

Cannabis-inspired medical products are garnering increasing attention from the scientific
community, general public, and health policy makers. A plethora of scientific literature …

In this proof-of-concept study, the antioxidant activity of phytocannabinoids, namely
cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC), were investigated using an in vitro …

Acute visceral pain relief mediated by A3AR agonists in rats... : PAIN Acute visceral pain relief
mediated by A3AR agonists in rats: involvement of N-type voltage-gated calcium channels …

Cannabidiol (CBD) has been generating increasing interest in medicine due to its
therapeutic properties and an apparent lack of negative side effects. Research has …

Type 1 cannabinoid receptors (CB 1 Rs) are expressed in the dorsal root ganglion (DRG)
and contribute to the analgesic effect of cannabinoids. However, the epigenetic mechanism …

Endocannabinoids play important roles in regulating CNS synaptic function and peripheral
metabolism, but cannabinoids can also act acutely to modulate contraction strength in …

Endocannabinoid system is considered a relevant player in the regulation of neuronal
excitability, since it contributes to maintaining the balance of the synaptic ionic milieu …

Marijuana or synthetic cannabinoids and alcohol are often used together, with these
combinations causing motor impairments that can subsequently lead to motor vehicle …

Circulating blood glucocorticoid levels are dynamic and responsive to stimuli that impact
autonomic function. In the brain stem, vagal afferent terminals release the excitatory …