There has been extensive progress in understanding the cellular and molecular
mechanisms of inflammation and immune regulation in allergic diseases of the skin and …

Autoimmune diseases, such as Systemic Lupus Erythematosus (SLE) or Rheumatoid
Arthritis (RA) are characterized by the breakdown of immunological tolerance. Defects of …

Allergic diseases are caused by a hypersensitivity reaction to an external substance that is
normally not harmful to the body. An imbalance between type 2 immune response and …

Primary atopic disorders describes a series of monogenic diseases that have allergy-or
atopic effector–related symptoms as a substantial feature. The underlying pathogenic …

abstract This review highlights recent advances in atopic dermatitis (AD) and food allergy
(FA), particularly on molecular mechanisms and disease endotypes, recent developments in …

Regulatory T (Treg) cells potentially suppress the deleterious activities of effector T cells and
maintain a state of tolerance against antigens in the airway mucosa. A decrease in the …

Type 2 inflammation and eosinophilic infiltration are prominent pathologic features of
chronic rhinosinusitis with nasal polyps (CRSwNP). The purpose of the present study was to …

Despite advances in research, the pathophysiology of food allergy has not yet been fully
elucidated. IL-10 has both a pro-and anti-inflammatory effect on the development of food …

食物过敏正在迅速发展成为全球性健康问题. 食物过敏反应是由无害食物特异性的Th2
反应引起, 导致IgE 介导的肥大细胞脱颗粒和相关的发炎反应. 食物过敏小鼠模型有助于对人类 …

Foxp3+ regulatory T cells (Tregs) are essential for the prevention of autoantibody and
allergen-specific IgE production. Treg deficiency causes an elevation of the serum levels of …