Large molecular machines regulate daily cycles of transcriptional activity and help generate
rhythmic behavior. In recent years, structural and biochemical analyses have elucidated a …

This review aims to summarize the knowledge about the relationship between circadian
rhythms and their influence on the development of type 2 diabetes mellitus (T2DM) and …

Post-translational control of PERIOD stability by Casein Kinase 1δ and ε (CK1) plays a key
regulatory role in metazoan circadian rhythms. Despite the deep evolutionary conservation …

Abstract Purpose of Review Blood pressure (BP) exhibits strong diurnal variations that have
been shown to be important for normal physiology and health. In this review, we highlight …

Daily fluctuations in animal physiology, known as circadian rhythms, are orchestrated by a
conserved molecular timekeeper, known as the circadian clock. The circadian clock forms a …

Ignoring the timing in the diagnostics and treatment of diseases becomes an anachronism.
The expression of most genes follows a circadian rhythm. Consequently, the existence of a …

Circadian rhythms are generated in mammals by a central clock located in the
suprachiasmatic nucleus of the hypothalamus, which regulates the homeostasis of many …

Forward genetics is a powerful approach to understand the molecular basis of animal
behaviors. Fruit flies were the first animal to which this genetic approach was applied …

Timing ist alles–auch im Krafttraining! Erreichen Sie mit dem richtigen Timing maximale
Performance: Wissenschaftler haben herausgefunden, dass jeder Muskel eine eigene …

An inactive, sedentary lifestyle directly impacts health and increases the risk of premature
death. Likewise, circadian rhythm disruption (eg, shift-work) is linked to various chronic …